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HIF-1α integrates metabolic and immunoregulatory programs in RORγt⁺ regulatory T cells during intestinal inflammation

Marcella Cipelli E. M. da Silva Luísa Menezes-Silva B. N. Padovani M. A. Amaral L. C. Paredes B. G. Nunes V. Yariwake J. N N. N. Bos A. G. da Silveira João Vinicius H. da Silva Raquel S. Vieira S. Yamada L. F. S. Moreira B. M. dos Santos A. Ignacio M. Forni O. Foresto-Neto J. Leite M. A. Vinolo D. D. da Fonseca S. Muxel Matthias Lochner Vinicius Andrade-Oliveira N. Câmara
Aug 2026 · bioRxiv · 0 citations · 79 references
Biology

TL;DR

HIF-1α is identified as a context-dependent checkpoint that connects hypoxia-responsive transcription to mitochondrial fitness and inflammatory plasticity in intestinal RORγt⁺ Treg.

DOI Semantic Scholar
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