This review critically summarizes mainly experimental and preclinical evidence linking dietary components, gut microbiota-derived metabolites, and ILC subsets to obesity, insulin resistance, type 2 diabetes mellitus (T2DM), and related metabolic complications.
HIF-1α is identified as a context-dependent checkpoint that connects hypoxia-responsive transcription to mitochondrial fitness and inflammatory plasticity in intestinal RORγt⁺ Treg.
Marcella Cipelli, E. M. da Silva, Luísa Menezes-Silva et al.· bioRxiv· 0 citations
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