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Matthias Lochner

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Open access Sep 2026

Activated macrophages restrict invasive bacterial infection in a human intestinal organoid co-culture model

A human colon organoid-derived monolayer co-culture system with macrophage-like THP-1 cells positioned directly beneath the epithelial layer is established, establishing a versatile human organoid-macrophage platform for dissecting epithelial-immune interactions and macrophage-associated control of invasive bacterial i...

Lisa F. Goertz, Marcella Cipelli, M. Buettner et al. · 0 citations

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