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It is suggested that butyrate enhances PTC metabolism and mitigates CaOx-induced injury, with potential implications for human AKI.
Current evidence regarding environmental exposure pathways, biodistribution, and molecular mechanisms of MNP-induced toxicity are integrated, emphasizing the need for integrated exposome-based approaches, omics technologies, advanced experimental models, and longitudinal studies to improve human health risk assessment...
HIF-1α is identified as a context-dependent checkpoint that connects hypoxia-responsive transcription to mitochondrial fitness and inflammatory plasticity in intestinal RORγt⁺ Treg.
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