A human colon organoid-derived monolayer co-culture system with macrophage-like THP-1 cells positioned directly beneath the epithelial layer is established, establishing a versatile human organoid-macrophage platform for dissecting epithelial-immune interactions and macrophage-associated control of invasive bacterial i...
Lisa F. Goertz, Marcella Cipelli, M. Buettner et al.· bioRxiv· 0 citations
BACKGROUND
Psoriasis is characterized by a pathogenic, hyperproliferative state of keratinocytes. While inflammation is known to drive this proliferation and induce metabolic reprogramming to regulate immune effector functions, the specific mitochondrial and metabolic alterations in keratinocytes during psoriatic infla...
Luís Eduardo Gonçalves, A. G. da Silveira, Luísa Menezes Silva et al.· Journal of dermatological sc...· 0 citations
This review critically summarizes mainly experimental and preclinical evidence linking dietary components, gut microbiota-derived metabolites, and ILC subsets to obesity, insulin resistance, type 2 diabetes mellitus (T2DM), and related metabolic complications.
HIF-1α is identified as a context-dependent checkpoint that connects hypoxia-responsive transcription to mitochondrial fitness and inflammatory plasticity in intestinal RORγt⁺ Treg.
Marcella Cipelli, E. M. da Silva, Luísa Menezes-Silva et al.· bioRxiv· 0 citations
It is argued that a comprehensive understanding of these multilevel interactions, from environmental conditions to cellular metabolism, is crucial for shaping effective prevention efforts, early diagnostic strategies, and evidence-based policies capable of mitigating the global rise of heat-associated kidney disease.
S. Yamada, Marcella Cipelli, P. F. Chagas et al.· Kidney360· 0 citations
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