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J. N

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Open access Aug 2026

HIF-1α integrates metabolic and immunoregulatory programs in RORγt⁺ regulatory T cells during intestinal inflammation

HIF-1α is identified as a context-dependent checkpoint that connects hypoxia-responsive transcription to mitochondrial fitness and inflammatory plasticity in intestinal RORγt⁺ Treg.

Marcella Cipelli, E. M. da Silva, Luísa Menezes-Silva et al. · bioRxiv · 0 citations