Skip to content
Log in
Sponsored Design Multi-Agent AI Systems Using MCP and A2A: Engineer your own Pyt Design Multi-Agent AI Systems Using MCP and A2A: Engineer your own Pyt
Open access

HIPPOCAMPAL TAU-RELATED SIGNAL INDEXES HYPEREXCITABILITY AND NREM SLEEP–MEMORY DYSFUNCTION IN TEMPORAL LOBE EPILEPSY

Thaera Arafat Katharina Schiller J. Lam N. von Ellenrieder Zheng-Chen Cai J. DeKraker F. Fadaie Viviane Sziklas Joelle Crane R. Cruces R. Hopewell C. Hsiao G. Massarweh J. Soucy Kjell Erlandsson S. A. Hosseini T. Chan Eliane Kobayashi Pedro Rosa-Neto A. Bernasconi N. Bernasconi Matthias J. Koepp J. Gotman B. Bernhardt
Sep 2026 · bioRxiv · 0 citations
Biology

TL;DR

It is suggested that hippocampal 18F-MK6240 uptake may represent a candidate marker of circuit vulnerability associated with NREM sleep-memory dysfunction in TLE, warranting validation in larger longitudinal studies.

DOI Semantic Scholar
Read PDF

Similar papers

Open access Sep 2026

Subcortical correlates of sleep in aging and Alzheimer’s disease: an in vivo study

Sleep disturbances are frequently observed in patients with neurodegenerative diseases, but in vivo evidence linking subcortical sleep–wake structures to sleep phenotypes is limited. We aim to examine associations between magnetic resonance imaging (MRI) –derived measures of subcortical sleep–wake regulating regions...

Agnès Pérez-Millan, Gerard Mayà, Isabel Martín-Sobrino et al. · 0 citations
Open access Aug 2026

DTI-ALPS index and cognitive performance in temporal lobe epilepsy with and without hippocampal sclerosis: a cross-sectional study.

BACKGROUND Temporal lobe epilepsy (TLE) often involves cognitive impairment, with hippocampal sclerosis (HS) as a key pathology. Although neuronal loss and proteinopathy are established mechanisms, the role of perivascular clearance pathways remains underexplored in TLE. OBJECTIVE This retrospective, single-centre cr...

Changqing Zhan, Xueping Lu, K. Linda Tang et al. · 0 citations
Open access Sep 2026

Brain-wide magnetic resonance imaging analysis of neurobehavioral comorbidities in temporal lobe epilepsy.

OBJECTIVE In temporal lobe epilepsy (TLE), patients often present with neurobehavioral comorbidities encompassing affective and cognitive difficulties. Whereas the latter have been related to atypical connectivity of mesiotemporal and frontotemporal circuits, the brain basis of affective symptoms remains incompletely u...

F. Fadaie, B. Caldairou, Boris C. Bernhardt et al. · 0 citations
Open access Sep 2026

Hippocampal Seizure-Related Burden is Associated with Accelerated Long-Term Forgetting in Focal Epilepsy.

OBJECTIVE Memory impairment is a frequent comorbidity of focal epilepsy, incompletely explained by seizure frequency or structural pathology. Ictal and postictal hippocampal dysfunction disrupt memory processes, but their cumulative impact remains poorly quantified. This study introduces cumulative hippocampal seizure-...

I. Bratu, I. Lambert, O. Felician et al. · 0 citations
Sep 2026

Subregion-specific temporal lobe EEG signatures in amnestic mild cognitive impairment: Evidence from high-density EEG.

BackgroundAmnestic mild cognitive impairment (aMCI), a prodromal stage associated with an increased risk of Alzheimer's disease (AD), is characterized by early neural network dysfunction. The temporal lobe is among the earliest affected regions, yet conventional electroencephalography (EEG) provides limited information...

Shi-Rui Wen, Jian-Ying Liu, Jing Wang et al. · 0 citations

We use cookies to run the site and, with your consent, for analytics and to show ads. See our Cookie Policy.