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Author

S. A. Hosseini

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Open access Sep 2026

Tau‐PET correlates of mild behavioral impairment in preclinical and prodromal Alzheimer's disease: A head‐to‐head comparison of Flortaucipir and MK6240

Abstract INTRODUCTION We compared the association between mild behavioral impairment (MBI) and first‐ versus second‐generation tau‐positron emission tomography (PET) tracers in preclinical and prodromal Alzheimer's disease (AD). METHODS We assessed 110 individuals with head‐to‐head [18F]MK6240 and [18F]Flortaucipir tau...

I. Bizzi, Arthur C. Macedo, Lydia Trudel et al. · 0 citations
Open access Sep 2026

HIPPOCAMPAL TAU-RELATED SIGNAL INDEXES HYPEREXCITABILITY AND NREM SLEEP–MEMORY DYSFUNCTION IN TEMPORAL LOBE EPILEPSY

It is suggested that hippocampal 18F-MK6240 uptake may represent a candidate marker of circuit vulnerability associated with NREM sleep-memory dysfunction in TLE, warranting validation in larger longitudinal studies.

Thaera Arafat, Katharina Schiller, J. Lam et al. · 0 citations
Open access Aug 2026

Predicting continuous amyloid PET levels with CSF and plasma brain‐derived p‐tau217

Conventional phosphorylated tau (p‐tau)217 reliably identifies amyloid positron emission tomography (PET) positivity, but its ability to capture the full Aβ continuum is limited.

Lydia Trudel, J. Therriault, Arthur C. Macedo et al. · 0 citations
Open access Aug 2026

Differential associations of tau extent and load with brain metabolic and cognitive dysfunction in Alzheimer's disease

Across regions and networks, SEOT performed similarly or better than tau load in predicting metabolic dysfunction and may improve diagnostic characterisation and prediction of cognitive impairment beyond [18F]FDG-PET.

Arthur C. Macedo, Lydia Trudel, S. A. Hosseini et al. · 1 citation

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