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It is suggested that hippocampal 18F-MK6240 uptake may represent a candidate marker of circuit vulnerability associated with NREM sleep-memory dysfunction in TLE, warranting validation in larger longitudinal studies.
Dysconnectivity of the temporal-parietal network emerges as a key contributor to affective symptoms in TLE, and limbic network dysfunction additionally impacts cognition, emphasizing the importance of multidisciplinary care targeting both emotion regulation and stress reduction, alongside cognitive rehabilitation, for...
These findings provide robust evidence that multiscale MRI profiling can identify FCD signatures and contribute to in-vivo subtyping and the novel use of myeloarchitecture profiling and contextualization with macro-scale brain gradients provides new avenues to understand intracortical alterations and the embedding of F...
Multi-site findings demonstrate marked thalamic circuit fragmentation in TLE, and robustly showed subdivision-specific effects, which point to both mesiotemporal co-lateralization as well as broader system-level involvement.
A hypometabolic gradient is identified in TLE, which covaries with cytoarchitectonic organization, microstructural changes, and hippocampal-neocortical interactions and provides a biologically grounded framework for precise surgical planning, emphasizing that targeting severe hypometabolism may optimize prognosis.
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