Youth adversity has been associated with alterations in hippocampal structure; however, it remains unclear whether different forms of adversity relate distinctly to its organization across the anterior-posterior and proximal-distal axes. Here, we investigated the associations of different types of adversity with multip...
It is suggested that hippocampal 18F-MK6240 uptake may represent a candidate marker of circuit vulnerability associated with NREM sleep-memory dysfunction in TLE, warranting validation in larger longitudinal studies.
Thaera Arafat, Katharina Schiller, J. Lam et al.· bioRxiv· 0 citations
A surface-intrinsic formulation of hippocampal unfolding is introduced in which geometry, intrinsic coordinates, and correspondence are defined directly on subject-specific surface manifolds, enabling topology-preserving alignment and more accurate characterization of inter-individual variability in health and disease.
J. DeKraker, D. Bansal, M. Snyder et al.· bioRxiv· 0 citations
HippoGenes provides a framework for exploring the molecular organization of the hippocampus, opening avenues for multiscale integration in health and disease, and is openly available on https://hippogenes.readthedocs.io.
A. Ngo, Sara Larivière, J. Royer et al.· bioRxiv· 0 citations
Multi-site findings demonstrate marked thalamic circuit fragmentation in TLE, and robustly showed subdivision-specific effects, which point to both mesiotemporal co-lateralization as well as broader system-level involvement.
Rui Ding, K. Xie, Judy Chen et al.· bioRxiv· 0 citations
A hypometabolic gradient is identified in TLE, which covaries with cytoarchitectonic organization, microstructural changes, and hippocampal-neocortical interactions and provides a biologically grounded framework for precise surgical planning, emphasizing that targeting severe hypometabolism may optimize prognosis.
J. Mo, F. Fadaie, J. Lam et al.· medRxiv· 0 citations
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