Open access
Inhibition of Moesin and CD44 in stem cell‐derived neurons affects the pathological genetic signature associated with Alzheimer's disease
Eiden H. Brewer
Charles A. Williams
Gregory A. Cary
R. Betarbet
I. Pranoto
E. Zoeller
Haian Fu
Allan I. Levey
Jesse C Wiley
Gregory W. Carter
Jessica E. Young
Medicine
Abstract
Post mortem proteomic analysis of Alzheimer's disease (AD) brain tissue has identified novel target genes and proteins for potential therapeutic development. Moesin (MSN) and CD44 were identified as candidate targets. Using human induced pluripotent stem cells (hiPSCs)‐derived neurons, we assayed how reducing gene expression of MSN and CD44 affected amyloid beta secretion, tau phosphorylation, and transcriptional state.