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Author

Jessica E. Young

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Open access Sep 2026

The Alzheimer's disease risk gene SORL1 is a regulator of excitatory neuronal function

Synaptic dysfunction is an early feature of Alzheimer's disease (AD) and proper localization of proteins involved in pre‐ and post‐synaptic composition is dependent on endosomal recycling and trafficking, cellular processes involving the AD risk gene sortilin‐related receptor 1 (SORL1).

C. Williams, Shannon E. Rose, Vera Stamenković et al. · 0 citations
Open access Aug 2026

Inhibition of Moesin and CD44 in stem cell‐derived neurons affects the pathological genetic signature associated with Alzheimer's disease

Using human induced pluripotent stem cells (hiPSCs)‐derived neurons, human induced pluripotent stem cells were assayed how reducing gene expression of MSN and CD44 affected amyloid beta secretion, tau phosphorylation, and transcriptional state.

Eiden H. Brewer, Charles A. Williams, Gregory A. Cary et al. · 0 citations

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