Open access
Dissecting Alzheimer's proteomic landscape through NULISA profiling of brain cell‐specific extracellular vesicles
Ashish Kumar
Mitu Sharma
Yixin Su
Sangeeta Singh
J. Tanley
Ramon Casanova
Fang-Chi Hsu
Suzanne Craft
M. M. Mielke
Timothy M. Hughes
Gagan Deep
Medicine
Abstract
Blood‐based biomarkers are essential for early detection, monitoring, and therapeutic development in Alzheimer's disease (AD) and related dementia (ADRD), but current assays lack brain cell specificity and sensitivity to low‐abundant proteins.