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Clarifying risk-factor associations with quantitative breast tumor features: a pooled analysis of 24 studies.

Daniel Adams Amber N. Hurson T. Ahearn I. Andrulis A. Antoniou P. Auvinen A. Bane S. Behrens Amy Berrington de González Katarzyna Białkowska C. Bodelon M. Bolla M. Borrero H. Brenner I. Brock A. Broeks N. Camp Melissa H. Cessna S. Chanock G. Chenevix-Trench E. Copson F. Couch A. Cox S. Cross P. Devilee A. Dunning D. Easton D. Eccles J. Figueroa G. Glendon A. González-Neira U. Hamann J. Hartikainen Mikael B. A. Hartman B. Heemskerk-Gerritsen P. Ho James M Hodge B. Holleczek A. Hollestelle M. Hooning A. Jakubowska Michael E. Jones L. Jones Brandt B. Jones A. Jung R. Kaaks R. Keeman Scott M. Lawrence Jingmei Li J. Lissowska J. Lubiński A. Mannermaa M. Manoochehri J. Martens W. Mesker N. Muhammad A. Mulligan N. Obi J. Olson A. Osorio Penelope D. Ottewell Alpa V. Patel G. Pita K. Prajzendanc M. U. Rashid Kathryn J. Ruddy F. Safizadeh B. Schöttker Petra Seibold W. Tapper M. Tengström L. Teras H. Thorne Mieke A Timmermans R. Tollenaar C. Vachon Qin Wang J. Wesseling S. Yadav Xiaohong R Yang M. Zamora J. Chang-Claude M. Schmidt Paul D. P. Pharoah M. Abubakar Montserrat García-Closas
Jul 2026 · Journal of the National Cancer Institute · 0 citations
Medicine

TL;DR

This pooled analysis of 15,731 cases showed that nulliparity, age at menopause, MHT, and BMI have independent, dose-response associations with ER, PR, and grade, clarifying patterns of etiologic heterogeneity.

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