Germline pathogenic or likely pathogenic variants (P/LPVs) in BRCA1 and BRCA2 are major determinants of hereditary breast and ovarian cancer susceptibility. Although clinical management has traditionally relied on the presence of a BRCA1/BRCA2 alteration regardless of its specific characteristics, growing evidence sugg...
Emma Zattarin, C. Piombino, E. Tenedini et al.· Critical reviews in oncology...· 0 citations
A comprehensive analysis of 60 CIMs provides limited evidence supporting broad causal effects of circulating inflammatory markers contributing to variation in MD phenotypes, although most instruments demonstrated weak conditional instrument strength after inclusion of BMI.
A. H. Suger, T. Harrison, C. Haas et al.· medRxiv· 0 citations
This pooled analysis of 15,731 cases showed that nulliparity, age at menopause, MHT, and BMI have independent, dose-response associations with ER, PR, and grade, clarifying patterns of etiologic heterogeneity.
Daniel Adams, Amber N. Hurson, T. Ahearn et al.· Journal of the National Canc...· 0 citations
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