Findings establish a mechanistic relationship between hydrophobic interaction-driven complexation, protein conformational remodeling, and delivery performance, highlighting β-lactoglobulin as a promising protein-based carrier for improving the delivery of bioactive compounds.
Qing Cen, Wei Wang, Jie Pan et al.· European Journal of Pharmace...· 0 citations
Ionizing radiation was associated with broad bidirectional transcriptional remodeling in 4T1 cells, involving immune-, inflammatory-, and interferon-related signatures together with reduced representation of cell-cycle- and DNA-repair-related gene sets.
Jing Li, Xin Bai, Wan-Jia Qiao et al.· International Journal of Rad...· 0 citations
The exponential growth of synthetically accessible chemical libraries, now exceeding tens of billions of molecules, creates unprecedented opportunities for drug discovery alongside formidable computational challenges. Conventional structure-based virtual screening such as docking, though foundational, struggles to scal...
Mohit Pandey· cIRcle (University of Britis...· 0 citations
This method takes advantage of the commonly observed, yet often undesired, in-source fragmentation of cholesteryl esters during electrospray ionization (ESI) to analyse cholesterol forms free and esterified in a single experiment, utilizing supercritical fluid chromatography (SFC) coupled with high-resolution mass spec...
Michaela Chocholoušková, Wai Kin Tham, Meng-Lan He et al.· Journal of Lipid Research· 0 citations
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This study systematically elucidated the Cu/Ni bioaccumulation characteristics and detoxification responses of the acid-tolerant microalga MA-1, and highlighted the importance of accounting for interactions of multiple metals when assessing the ecological risks of heavy metal combined pollution.
Meng-Lei Ye, Dan-Dan Zhang, Huang Yang et al.· Environmental Pollution· 0 citations
Leptospirosis, a widespread zoonotic disease caused by Leptospira interrogans, poses a major public health challenge, particularly in tropical regions. Despite progress in genomic studies, many putative virulence factors (VFs) remain uncharacterized. This study focuses on LIC10280, a conserved hypothetical protein iden...
Zhen-Pei Wong, Aik-Hong Teh, Emiko Sanada et al.· Microbial Pathogenesis· 0 citations
The engineered tBE (etBE) exhibited substantially enhanced editing efficiencies compared with the parental tBE, while maintaining high editing fidelity and background levels of OT mutations, and represents a highly efficient and specific base editing platform with enormous potential for both basic research and clinical...
Bo-Wen Chen, Le-Tong Liang, Ruijuan Xu et al.· Advancement of science· 0 citations
Fluorogen-activating proteins enable low-background fluorescence imaging by inducing emission only upon fluorogen binding. However, spectral diversification often involves coordinated optimization of fluorogens and their protein partners, while compatibility with structurally diverse fluorophore scaffolds remains limit...
Pu Meng, Zhuang Shao, Kai Cui et al.· Organic and biomolecular che...· 0 citations
Plasma protein and metabolite profiles differ between persistent AF and SVT, and eight shared dysregulated pathways linked to energy metabolism are revealed.
Jun Wang, Xiao-Zhen Chen, Zi-Lan Zhang et al.· International Journal of Car...· 0 citations
Cr(VI) is a priority soil contaminant, yet current earthworm toxicity assessments still rely largely on single-species apical endpoints. In this study, we systematically compared the sensitivity of 12 earthworm species, representing epigeic, endogeic and anecic life forms, to Cr(VI) using four response indicators spann...
Lei Yu, Meng Wang, L. Qin et al.· Environmental Pollution· 0 citations
ABD035-C9-C9-DOTA is a promising candidate for the development of targeted RPT of CEACAM5-expressing tumors and a significant increase in the survival of tumor-bearing mice and mild, transient toxicity is demonstrated.
Ruo-Nan Li, E. Papalanis, M. Oroujeni et al.· Journal of Nuclear Medicine· 0 citations
This study addresses a major bottleneck in dairy waste management by engineering a highly efficient, thermophilic enzyme for lactose hydrolysis, transforming the cheese manufacturing by-product whey into a high-value resource. While traditional glycoside hydrolase family 2 (GH2) enzymes suffer from poor industrial ther...
Si-Meng Ding, Jia-Jia Li, Jia-Hui Li et al.· Journal of Dairy Science· 0 citations
A new machine-learning framework aims to improve the success rate of computational protein design while moving away from results that reproduce sequences found in nature.
