Looking beyond natural sequences
A new machine-learning framework aims to improve the success rate of computational protein design while moving away from results that reproduce sequences found in nature.
More from the blog
GPT-Lab
· gpt-lab.eu
Sep 17, 2026
Beyond Prompt Engineering: The Role of Tacit Knowledge in Software Engineering
AI is making software generation faster, but speed does not remove the need for expertise. As more work is delegated to AI, tacit knowledge may become one of the most important human advantages in software engineering. The post Beyond Prompt Engineering: The Role of Tacit Knowledge in Software Engineering appeared first on GPT-Lab.
GPT-Lab
· gpt-lab.eu
Sep 10, 2026
Responsible AI Must Consider Its Afterlife
AI may appear weightless, but every model depends on physical infrastructure. To understand responsible AI, we need to look beyond algorithms and consider the entire lifecycle of the hardware behind them. The post Responsible AI Must Consider Its Afterlife appeared first on GPT-Lab.
GPT-Lab
· gpt-lab.eu
Aug 19, 2026
Zero Human Organization
What happens when AI moves beyond automating individual tasks and starts operating an organization? GPT-Lab’s Zero Human Organization experiment explores what becomes possible when AI takes on the day-to-day operational loop. The post Zero Human Organization appeared first on GPT-Lab.
Seeing beyond BMI: Estimating cardiometabolic risk with smartphone imagery
General Science
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What Influences the Speed of Prototyping? An Empirical Investigation of Twenty Software Startups
This study conducts a multiple case study on twenty European software startups and proposes a prototype-centric learning model in early stage software startups, and identifies factors that occur as barriers but also facilitators for prototyping in earlystage software startups.
PepPCBench is a Comprehensive Benchmarking Framework for Protein-Peptide Complex Structure Prediction
PepPCBench enables a robust evaluation of PFNN-based methods and supports their continued development for peptide-protein structure prediction, and highlights the influence of peptide length, conformational flexibility, and training set similarity on prediction accuracy.
Computational and AI-Driven Ecosystem for Structure-Based Covalent Drug Discovery.
This Account describes a computational and AI-driven ecosystem for structure-based covalent drug discovery and dives into a suite of cutting-edge, AI-driven computational methods, exploring the potential of deep learning in tasks such as molecular docking, covalent binding site prediction, and lead optimization.
PepBAN: A Deep Learning Framework with Bilinear Attention and Adversarial Learning for Peptide-Protein Interaction Prediction
PepBAN is introduced, a deep learning framework for modeling PepPI predictions that effectively learns the pattern of pairwise local interactions, enables the identification of key residues participating in the peptide-protein interactions, and offers an intuitive approach to interpret the underlying mechanisms of PepPIs via analyzing attention weights.