Among phage-derived antimicrobial molecules, holins are membrane-active proteins that play a central role in bacterial lysis; however, the contribution of their individual structural domains to antibacterial activity remains poorly understood. In this study, we investigated the functional role of the extended C-termina...
Cryopreservation is fundamental for mesenchymal stem cell (MSC) banking, but the freeze–thaw cycle induces sub-cellular stress, potentially modifying the post-thaw genomic and paracrine identity of the cellular product. This study aimed to compare the biological, molecular, and functional stability of fresh and cryopre...
G. Esmael· Scientific Progress & In...· 0 citations
Microfluidic chips are promising for on-site analysis in medical diagnostics and food safety because they enable miniaturized, integrated sample processing. However, the analysis of complex, salt-rich matrices of biological and food samples remain challenging for conventional closed chips and electrokinetic pretreatm...
Jicheng Niu, Wenxuan Fu, Bin Su et al.· Analytical Chemistry· 0 citations
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Abstract: This study presents a testable quantum-informational and biophysical framework to resolve two of the most fundamental crises in theoretical physics and observational cosmology: the Cosmological Constant Catastrophe ($10^{120}$ discrepancy) and the late-time cosmic acceleration transition ($z \approx 0.5$). Mo...
Ali Göktürk Özdoğan· Zenodo (CERN European Organi...· 0 citations
Abstract: This study presents a testable quantum-informational and biophysical framework to resolve two of the most fundamental crises in theoretical physics and observational cosmology: the Cosmological Constant Catastrophe ($10^{120}$ discrepancy) and the late-time cosmic acceleration transition ($z \approx 0.5$). Mo...
Ali Göktürk Özdoğan· Zenodo (CERN European Organi...· 0 citations
This dataset contains the AlphaFold2, AlphaFold3 and integrative structural models, together with native mass spectrometry and mass photometry data, underlying Haas et al., “Integrative structure of norovirus NS3 suggests a role in RNA transport”. Norovirus NS3 is a membrane-bound AAA+ ATPase of superfamily 3 (SF3). Th...
Meryl Haas, T. Hoeksma, Cynthia Kelley et al.· Zenodo (CERN European Organi...· 0 citations
This dataset contains the AlphaFold2, AlphaFold3 and integrative structural models, together with native mass spectrometry and mass photometry data, underlying Haas et al., “Integrative structure of norovirus NS3 suggests a role in RNA transport”. Norovirus NS3 is a membrane-bound AAA+ ATPase of superfamily 3 (SF3). Th...
Meryl Haas, T. Hoeksma, Cynthia Kelley et al.· Zenodo (CERN European Organi...· 0 citations
Findings support a conserved capacity of selected classical adhesins to serve as candidate docking partners for exogenous Gpm1 and demonstrate the ability of surface-associated Gpm1 to interact with the host contact system components across pathogenic yeasts.
Opilowska Aleksandra, G. Satała, Rapala-Kozik Maria et al.· Microbial Pathogenesis· 0 citations
A surface display strategy is utilized to construct an adhesion‐enhanced Escherichia coli Nissle 1917 chassis that effectively alleviates inflammation, restores epithelial barrier integrity, and reverses oxidative damage in both prophylactic and therapeutic murine colitis models.
Yu-Xi Wang, Pei-Chao Zhang, Si-Min Gu et al.· Advancement of science· 0 citations
Extracellular vesicles (EVs) mediate intercellular transfer of lipids, proteins, and nucleic acids between cell types. We previously showed that astrocyte-derived EVs modulate neuronal mitochondria in vitro. Whether endogenous astrocytic EVs associate with neuronal mitochondria in vivo remained unknown. To address this...
Xiao-Jia Ren, Zainuddin Quadri, Zhi-Hui Zhu et al.· The FASEB Journal· 0 citations
A 125-plex Sb secretion construct library was developed consisting of all possible combinations of five promoters, five secretion signals, and five terminators, which enabled a greater than 1800-fold range in Sb expression of a Gaussia luciferase (GLuc) reporter.
Miranda J. Wallace, Christina Kratschmer, Brandon Brazil et al.· Trends in Biotechnology· 0 citations
A new machine-learning framework aims to improve the success rate of computational protein design while moving away from results that reproduce sequences found in nature.
