BACKGROUND AND AIMS
Stem lignification seriously reduces the edible quality and marketability of Pteridium aquilinum, a popular wild vegetable. This study aimed to explore the molecular mechanism underlying stem lignification during longitudinal development.
METHODS
We performed 4D-proteomics based on data-independen...
It is proposed that proteostasis functions as an active physiological signaling network that governs islet cell adaptation, plasticity, and long‐term homeostasis, extending beyond its conventional role in the response to cellular damage.
Jun Shirakawa· Journal of Diabetes Investig...· 0 citations
The cellular export of large-sized proteins, such as collagen or fibrillin, necessitates a specialized transport pathway tailored towards their size. For collagen and possibly also other bulky proteins, the Transport ANd Golgi Organization 1 (TANGO1) protein plays a substantial role in the transfer from the Endoplasmic...
Jelena Auch, Anna Carlotta Peddinghaus, Raphael Stoll· Biomolecular NMR Assignments· 0 citations
This work incubates freshly collected freshwater Achromatium under three temperature conditions and provides the first indication that Achromatium uses distinct protein variants under different environmental conditions, enabling it to swiftly respond to environmental changes through differential expression from its cac...
Sophie-Luise Heidig, Sunu Lama, J. Rijal et al.· bioRxiv· 0 citations
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A series of alkyl coumarin-tethered phenyl quinazolinones were rationally designed and synthesized as hypoxia-targeted dual hCA IX/HSP90α inhibitors, exhibiting potent, highly selective inhibition of hCA IX (in the nanomolar range), while displaying negligible activity against the off-target isoforms hCA I and II.
Amal S. Elgohary, Mervat H. El-Hamamsy, N. Sharafeldin et al.· RSC Advances· 0 citations
A directed engineering strategy is employed combining energy-based screening and protein language models to obtain a triple mutant, TIG, which enhances residue flexibility and remodels the ATP-binding pocket, thereby improving DNA-binding pathway connectivity and strengthening the coupling between ATP hydrolysis and DN...
Ling-Song Li, Lin Zhang, Dong-Xia Li et al.· International Journal of Bio...· 0 citations
It is shown that a zebrafish protein, drP18, can transition into an amyloid fold, driven by a sophisticated two-cysteine oxidation mechanism, suggesting that oxidation-driven amyloid formation can act as a more general mechanism of protein regulation.
A. Sethi, Hannah Darroch, N. J. Magon et al.· bioRxiv· 0 citations
Investigation of the role of FKBP1A in PAAD, its correlation with known biomarkers and its association with tumor progression and patient survival suggests that FKBP1A might be a crucial prognostic biomarker for PAAD.
Unknown authors· Research journal of biotechn...· 0 citations
This review systematically summarizes the full technological chain for efficient and high-quality mAb production, focusing on three levels: cell line construction, culture medium development, and process regulation in bioreactors, and highlights their key strategies, mechanisms, and synergistic relationships.
Xin-Wei Su, Jianquan Luo, Rong Fan et al.· Chem & Bio Engineering· 0 citations
Novel post-translational mechanisms within chloroplasts that allow cells to monitor heat stress and initiate a response are revealed that can respond to heat and affect plant growth and development.
The fold and mechanistic diversity of Diels–Alderases are expanded, an exo-selective β-propeller pericyclase superfamily is defined, and a new handle for mining and bioengineering cis-decalin biosynthetic pathways is provided.
Unknown authors· Journal of the American Chem...· 0 citations
A new machine-learning framework aims to improve the success rate of computational protein design while moving away from results that reproduce sequences found in nature.
