Background Schizophrenia (SCZ) is a highly heterogeneous psychiatric disorder in which rare missense variants are increasingly recognized as major contributors to disease risk. Recent advances in next-generation sequencing (NGS), AlphaFold-based protein structure prediction, and machine learning provide unprecedented o...
Shaolei Teng, Malcolm Anthony, Qiaobin Yao et al.· European Neuropsychopharmaco...· 0 citations
PAIRWISE: Deep Learning-based Prediction of Effective Personalized Drug Combinations in CancerPAIRWISE predicts whether a drug pair acts synergistically in a specific tumour sample. It fuses three modalities — molecular graphs of the two compounds, theirdrug–target interaction profiles propagated over a protein–protein...
A) Western blot shows FGFR1 protein levels in WT-MCF7 and TR-MCF7 cells. GAPDH was as loading control. B) Relative expression of FGFR1 in WT-MCF7 and TR-MCF7 cells, measured by RT–qPCR and normalized to ACTB and RPLP1. Fold change was calculated relative to the geometric mean of ΔCq of the MCF7-WT condition. C) Western...
Torbjørn Amundsen. Lien, Sushil Dhakal, Anne Marthe. Fosdahl Wium et al.· 0 citations
Ferroptosis-related pathways have been implicated in cardiovascular remodeling and cancer, but their relevance to hypertensive heart disease (HHD) remains uncertain. This study examined transcriptomic patterns in a dilated cardiomyopathy (DCM) dataset and used pan-cancer data only for descriptive context; it did no...
Ming-Wei Yang, Hua-Yin Li, Fang-Chao Wang et al.· Frontiers in Genetics· 0 citations
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Pancreatic beta cells face exceptional protein folding demands from high insulin production requirements, placing extraordinary stress on the endoplasmic reticulum (ER) and contributing to dysfunction in diabetes pathogenesis. Monitoring ER stress dynamics in living cells remains challenging due to the destructive natu...
Eric J. Floro, Alex M. Bennett, Romario Regeenes et al.· ACS Sensors· 0 citations
Background Schizophrenia (SCZ) and bipolar disorder (BD) share considerable genetic risk andoverlap in clinical presentation, yet the nature and extent of their molecular convergence, particularly in relation to illness progression, remains insufficiently defined. Cerebrospinal fluid(CSF) proteomics offers a minimally...
Andreas Göteson, Elin Hörbeck, Robert Sigström et al.· European Neuropsychopharmaco...· 0 citations
Pancreatic ductal adenocarcinoma (PDAC) is characterized by marked molecular and epithelial heterogeneity, but the cross-cohort and cellular context of candidate genes remains incompletely resolved. We integrated bulk transcriptomic and proteomic data with patient-grouped machine-learning assessment, independent-cohort...
The therapeutic potential of piperlongumine (PL) against schistosomiasis and hepatic injury is limited by its poor water solubility. Herein, well-defined, monodisperse, surface glucose-functionalized, and PL-encapsulated nanoparticles (PL-NPs) with uniform size (hydrodynamic diameter: ∼264 nm) were synthesized via a...
Xiu-Long Deng, Xueqin Mu, Xiao-Liang Li et al.· ACS Applied Nano Materials· 0 citations
HSPA5 is a member of the HSP70 family of heat shock proteins (HSPs) and functions as a chaperone protein within the endoplasmic reticulum (ER). It plays a role in maintaining ER homeostasis, assists in correct protein folding, and triggers the unfolded protein response. Environmental toxins–such as heavy metals, microp...
Yu-Rong Wang, Yan-Xin-Xia-Chun-Hui-Chen-Xue-Wang-Yu-Lun-Zhi-Qian Lv, Rui-Dong Zhao et al.· Frontiers in Molecular Neuro...· 0 citations
Occupational heat and blast overpressure impair spermatogenesis, and whether repair capacity supplied from outside the germ cell can lift the resulting block has not been tested. GC-2 spermatocytes received 1000 shock-wave pulses then 100°C for 40 s, and C57BL/6 mice received a 10% methane blast with intratesticular te...
Jiahua Meng, Zitong Zhang, Ning Li et al.· Figshare· 0 citations
Protein hydrogels are promising artificial extracellular matrices (ECMs) for 3D stem cell and organoid culture due to their favorable stress relaxation behavior (a decrease in stress in response to strain). Inter-chain entangled motifs, in which different protein chains are interlaced, represent a powerful strategy t...
Pu-Qing Deng, Yu-Tong Wu, Hong Kiu Francis Fok et al.· Nature Communications· 0 citations
PAIRWISE: Deep Learning-based Prediction of Effective Personalized Drug Combinations in CancerPAIRWISE predicts whether a drug pair acts synergistically in a specific tumour sample. It fuses three modalities — molecular graphs of the two compounds, theirdrug–target interaction profiles propagated over a protein–protein...
A new machine-learning framework aims to improve the success rate of computational protein design while moving away from results that reproduce sequences found in nature.
