Background Genome-wide association studies (GWAS) have identified dozens of loci for autism and related neurodevelopmental disorders (NDDs), yet pinpointing causal variants remains challenging. Standard fine-mapping assumes the causal variant is a SNP present in reference panels, but common structural variants (SVs)—de...
Yundan Liao, Michael Gandal· European Neuropsychopharmaco...· 0 citations
Abstract Nattokinase (NK) is an orally administered subtilisin-family serine protease with reported activity across multiple interconnected proteolytic and cardiovascular targets, including degradation of SARS-CoV-2 spike protein, fibrinaloid amyloid microclots, fibrin clots, and classical amyloid substrates; enhanceme...
Nicolas Hulscher, Harvey A. Risch, James A. Thorp et al.· Zenodo (CERN European Organi...· 0 citations
Since its discovery in 2016, the RNA-targeting CRISPR-Cas13 protein is widely adopted for precise knockdown of target RNAs in human cells. However, conflicting reports from different groups over the years raised questions about the specificity of Cas13 knockdown. The ambiguity largely stems from the fact that the exact...
Reductive dehalogenase homologs (RdhA) are widespread and structurally diverse across prokaryotes, but it remains unclear whether their major architectural classes differ systematically in how mobile they are, how often they transfer, where they sit taxonomically, and which habitats they occupy. We screened GTDB r220 a...
Background Schizophrenia (SCZ), bipolar disorder (BD) and major depressive disorder (MDD) are leading causes of disability, still only few biomarkers are available to optimise treatment prescription. As a matter of fact, about a third of patients suffering from these diseases do not respond to multiple pharmacological...
Chiara Fabbri, İnci Aksoylu, Sergi Papiol et al.· European Neuropsychopharmaco...· 0 citations
GDSL esterase/lipase (GELP) proteins are involved in lipid metabolism, cell wall modification, and plant immune regulation; however, their genome-wide characterization and potential roles in watermelon responses to Meloidogyne incognita infection remain largely unexplored. Through genome-wide analysis, 75 ClGELP family...
Curated dataset and analysis code for a deduplicated census of the mobilized colistin resistance (mcr) gene family in the August 2026 NCBI snapshot (AMRFinderPlus Reference Gene Catalog 2026-08-07.1). Contents. Four archives: (1) core curated datasets (1,298 → 1,106 records, 454 unique proteins, 284-protein QC-triage c...
Shilei Dong· Zenodo (CERN European Organi...· 0 citations
Background/Objectives: Relapse remains the leading cause of mortality in pediatric acute lymphoblastic leukemia (ALL), underscoring the need for novel biomarkers and therapies. The objective of this study is to identify distinct metabolomes associated with relapsed ALL, using bone marrow aspirated at the relapse episod...
Background Autism spectrum disorder (ASD) is a common, heritable, polygenic neurodevelopmental disorder, with hundreds of robustly associated risk genes and loci. Transcriptomic profiling of post-mortem cortex has identified characteristic ASD molecular signatures, including upregulation of protein folding pathways and...
Rachel L. Smith, Michael Jeffrey Gandal· European Neuropsychopharmaco...· 0 citations
Osimertinib is a third-generation, irreversible EGFR inhibitor that targets common activating EGFR mutations (ex19del and L858R) and the resistance EGFR mutation T790M. Clinical resistance to osimertinib frequently arises through the EGFR C797S mutation, which has driven the development of fourth-generation EGFR in...
Janneke J. Melis, Kirsten J. Kevenaar, J. Ytsma et al.· Frontiers in Oncology· 0 citations
A) Western blot shows FGFR1 protein levels in P-T47D and TR-T47D cells. GAPDH as loading control. (B–C) Relative expression of FGFR1 and STING1 respectively, in P-T47D and TR-T47D cells, measured by RT-qPCR and normalized to ACTB and RPLP1. Fold change was calculated relative to the geometric mean of ΔCq of the P-T47D...
Torbjørn Amundsen. Lien, Sushil Dhakal, Anne Marthe. Fosdahl Wium et al.· 0 citations
Since its discovery in 2016, the RNA-targeting CRISPR-Cas13 protein is widely adopted for precise knockdown of target RNAs in human cells. However, conflicting reports from different groups over the years raised questions about the specificity of Cas13 knockdown. The ambiguity largely stems from the fact that the exact...
A new machine-learning framework aims to improve the success rate of computational protein design while moving away from results that reproduce sequences found in nature.
