DNA nanostructures are programmable, biocompatible platforms for biomedicine; however, their mechanical properties are coupled to sequence and structural dimensions, limiting control over stiffness. Here, we report a paradigm shift from static design to mechanical engineering of DNA nanostructures. Using a nanoemulsion...
Fan Yang, Min-Chao Liu, Qian-Qian Lu et al.· Angewandte Chemie· 0 citations
Fig. 1: Integrated valorization pathway for sustainable food processing, illustrating the conversion of agro-waste and seaweeds into high-value proteins, starch, dietary fibres, bioactive compounds, and functional polysaccharides through green extraction technologies, followed by their application in active and intelli...
This work establishes spatial conformation as a programmable parameter for regulating nanoparticle biodistribution and clearance, thereby shifting the design paradigm from compositional adjustment to architectural control and opening avenues for targeted delivery, imaging, and immunotherapy.
Qian Chen, Fei Ding, Shuang-Ye Zhang et al.· ACS Applied Materials and In...· 0 citations
Background: Idiopathic normal pressure hydrocephalus (iNPH) is a potentially treatable neurological disorder whose molecular basis remains incompletely understood. Metabolomic studies in iNPH are scarce and have focused largely on comparisons with other neurological disorders or on cerebrospinal fluid (CSF) alone. Cons...
D. Visentin, D. Vukas, Z. Kolić et al.· medRxiv· 0 citations
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Microalgae are a source of valuable compounds with broad applications in cosmeceuticals, nutraceuticals, renewable energy, and bioremediation. The present study employs the freshwater microalgae Tetradesmus dimorphus NUAC202 to investigate the effects of different microalgal growth media, like BG-11, Bold’s basal mediu...
P. Pongpadung, Nittaya Saninsi, Sunanthakan Khumman et al.· Journal of Phytology· 0 citations
Abstract Nattokinase (NK) is an orally administered subtilisin-family serine protease with reported activity across multiple interconnected proteolytic and cardiovascular targets, including degradation of SARS-CoV-2 spike protein, fibrinaloid amyloid microclots, fibrin clots, and classical amyloid substrates; enhanceme...
Nicolas Hulscher, Harvey A. Risch, James A. Thorp et al.· Zenodo (CERN European Organi...· 0 citations
Coronavirus disease 2019 (COVID-19) is frequently accompanied by extrapulmonary manifestations, including abnormal liver biochemistry. Although inflammatory markers are widely used in clinical assessment, their associations with hepatic biochemical abnormalities in hospitalized patients with COVID-19 remain incompl...
Omar Alomair· Frontiers in Public Health· 0 citations
The cardiovascular effects of smoking are generally evaluated in the context of acute ischemic injury. The possible association of smoking with subclinical cardiac autoimmunity and oxidative/inflammatory processes has been examined in relatively few studies. In this cross-sectional pilot study, we compared levels of ca...
Cronkhite-Canada syndrome (CCS) is an extremely rare non-hereditary syndrome (approximately 500 cases reported worldwide), characterized by diffuse gastrointestinal polyposis, ectodermal changes (alopecia, skin hyperpigmentation, onychodystrophy), and protein-losing enteropathy. Patients with CCS have a significantly i...
Min Li, Lun Li, Tao Wang· BMC Gastroenterology· 0 citations
High-spatial-resolution in situ mapping of biomolecules within tissue reveals critical insights into the complex molecular landscape and spatial organization of biological systems. Mass spectrometry imaging (MSI) is a powerful tool for spatially resolved molecular analysis of biological samples, with ongoing demand for...
Hua Zhang, Lang Ding, Thao U. Duong et al.· Nature Protocols· 0 citations
Background/Objective: Metabolic dysfunction-associated steatohepatitis (MASH), an advanced stage of metabolic dysfunction-associated steatotic liver disease (MASLD), is characterized by progressive liver fibrosis and represents an important therapeutic target. NP-011 is a truncated recombinant human milk fat globule EG...
Hyunjung Lee, Q. Tran, Tham Thi Bui et al.· Pharmaceutics· 0 citations
The spliceosome became very complex in eukaryogenesis. The Group IIA intron progenitor was associated with a single protein, homologous to spliceosomal Prp8, but the LECA spliceosome included ~140 proteins. The acquisition of proteins was a neutral process, providing a pool of factors for the development of a coordinat...
Olga V. Artemyeva-Isman· Preprints.org· 0 citations
A new machine-learning framework aims to improve the success rate of computational protein design while moving away from results that reproduce sequences found in nature.
