Nisin is a widely used antimicrobial peptide with strong inhibitory activity against Gram-positive bacteria and growing interest for broader biomedical applications. However, its practical use is limited by susceptibility to environmental conditions, reduced stability, and rapid inactivation. Encapsulation has emerged...
Mesophilic enzymes are often less active at low and moderate temperatures than their psychrophilic homologues. The earthworm Eisenia fetida has cold-adapted enzymes, but the end-β-1,4-mannanase shows weaker activity at low temperatures compared with other E. fetida enzymes. Cold-adapted enzymes need flexible structur...
Yu Hirano, Yuki Naka, Yuya Hanazono et al.· Journal of Agricultural and...· 0 citations
Building on the first collection on the topic, the second volume comprises seven original research articles, two case reports, one perspective, and one systematic review.Three research papers focus on rheumatoid arthritis (RA)-related biomarkers and inflammatory mechanisms, spanning cell death, cardiovascular complicat...
Li Zeng, Jian Liu· Frontiers in Immunology· 0 citations
ABSTRACT Fecal microbiota transplantation (FMT) carries a risk of infection. Cell-free fecal filtrate transplantation (FFT) represents a potentially safer alternative. The benefit of FFT has not been explored in alcohol-associated liver disease (ALD). We evaluated the therapeutic potential of FFT in a murine model of A...
Nishu Choudhary, Ashi Mittal, Kavita Yadav et al.· Microbiology spectrum· 0 citations
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Abstract Glucagon‐like peptide‐1 (GLP‐1), secreted by enteroendocrine L cells, plays a crucial role in glucose homeostasis and appetite regulation. The identification of food‐derived bioactive compounds capable of stimulating endogenous GLP‐1 secretion has attracted increasing attention in the development of functional...
Hongdong Song, Shaoxia Ren, FU Qiuyun(傅秋云) et al.· Food biomacromolecules.· 0 citations
Endoplasmic reticulum-associated degradation (ERAD) must dynamically adapt to cellular protein-folding demands, yet mechanisms regulating ERAD-associated adaptors remain incompletely defined. Here, we identify the E3 ubiquitin ligase RNF5 as a regulator of the ERAD adaptors HERPUD1 (HERP1) and OS9. RNF5 depletion incre...
Biophysical principles underlying peptide-mediated modulation of ion channels support a framework in which ion-channel modulation emerges from the coupled behavior of peptide, lipid bilayer, and membrane protein rather than from toxin binding alone.
Diego Santos Souza, Camila Dourado, Pedro V. Moraes-Santos et al.· Biophysical Reviews· 0 citations
Background Liver depression syndrome (LDS) is a core Chinese medicine (CM) syndrome implicated in the onset and progression of breast cancer, whose molecular mechanisms remain poorly understood, hindering further investigation. Methods We prospectively enrolled 146 participants and conducted transcriptomic, proteomic,...
Qianqian Guo, Jieting Chen, Geng Yang et al.· Frontiers in Immunology· 0 citations
TIR domains are found in diverse immune signaling proteins and, in several systems, function as NAD+-cleaving enzymes causing or signaling cell death. In plants, TIR domains occur as effector domains in TNL immune receptors, where they are coupled to a central STAND ATPase and a C-terminal repeat domain. Here, we ident...
Joëlle Hornebeck, Р. Б. Ибрагимов, Nicole Oelerich et al.· bioRxiv· 0 citations
Ischemic stroke is a leading cause of mortality and long-term disability worldwide, yet its underlying molecular mechanisms remain incompletely understood. The pathology involves complex interactions between vascular injury, immune dysregulation, metabolic imbalance, and mitochondrial dysfunction. Traditional single-...
S. Nirala, Sandeep Kumar Shah· Frontiers in Pharmacology· 0 citations
ABSTRACT DNA nanostructures are programmable, biocompatible platforms for biomedicine; however, their mechanical properties are coupled to sequence and structural dimensions, limiting control over stiffness. Here, we report a paradigm shift from static design to mechanical engineering of DNA nanostructures. Using a nan...
Fan Yang, Minchao Liu, Qianqian Lu et al.· Angewandte Chemie· 0 citations
DNA nanostructures are programmable, biocompatible platforms for biomedicine; however, their mechanical properties are coupled to sequence and structural dimensions, limiting control over stiffness. Here, we report a paradigm shift from static design to mechanical engineering of DNA nanostructures. Using a nanoemulsion...
Fan Yang, Min-Chao Liu, Qian-Qian Lu et al.· Angewandte Chemie· 0 citations
A new machine-learning framework aims to improve the success rate of computational protein design while moving away from results that reproduce sequences found in nature.
