Introduction Choledocholithiasis or common bile duct stones (CBDS) is a frequent cause of hospitalization. Confirmed stones are usually removed by Endoscopic Retrograde Cholangiopancreatography (ERCP), but this procedure carries significant risks (infection, perforation, hemorrhage). Current guidelines from the Europea...
We present a theoretical and numerical study of protein folding kinetics and conformational transitions in complex free-energy landscapes using generalized Langevin equations with memory kernels and Fokker-Planck formalisms. Moving beyond standard deterministic approaches, we investigate non-equilibrium folding dynamic...
Henrietta Volkova· Zenodo (CERN European Organi...· 0 citations
Avian pathogenic Escherichia coli (APEC) causes substantial economic losses in the poultry industry, and vaccines capable of providing protection across diverse APEC strains remain needed. In this study, a FimH-CsgA-OmpA multiepitope fusion antigen (MEFA) was constructed and evaluated for immunogenicity, in vitro anti-...
Jiayu Cui, Mingqing Shao, Long Wang et al.· Life· 0 citations
Porcine epidemic diarrhea virus (PEDV) remains a major threat to the global swine industry, with current inactivated vaccines offering limited cross-protection due to imperfect antigen design and weak immune activation. Here, we engineered a full-structural-protein virus-like particle (VLP) co-assembled with PEDV S, M,...
Fei-Yang Jiang, Lian-Mei Bai, Yan-Yuan Zhang et al.· ACS Applied Materials and In...· 0 citations
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Abstract: Classical AI answers from inside a representation fixed before the question arrives. What that representation can express, the system can answer; what lies outside it, no amount of parameters, data, search, or compute reaches. AlphaFold predicts through a learned representation; AlphaEvolve searches a space o...
Denise Holt, Denis Ovseyenko· Zenodo (CERN European Organi...· 0 citations
In this investigation, the antioxidant capacity of stirred-type hypoallergenic and lactose-free yogurt was improved using cylindra-type beetroot peel extract. Milk proteins were hydrolyzed with papain at different concentrations (0.008 g·L−1 and 0.012 g·L−1) and, subsequently, milk with papain-hydrolyzed proteins were...
Kenbon Beyene Abdisa, Moh Moh Zin, Adrienn Vargáné Tóth et al.· Applied Sciences· 0 citations
Abstract Alternative splicing (AS) is dysregulated in pediatric CNS tumors, including high-grade gliomas (HGGs) and atypical teratoid/rhabdoid tumors (ATRTs) which have poor survival outcomes and urgently need new therapeutic strategies. AS is increasingly being explored as a source of tumor-specific antigens for immun...
Ryan Corbett, Meghali Goswami, Patricia Sullivan et al.· Cancer Research· 0 citations
We present a theoretical and numerical study of protein folding kinetics and conformational transitions in complex free-energy landscapes using generalized Langevin equations with memory kernels and Fokker-Planck formalisms. Moving beyond standard deterministic approaches, we investigate non-equilibrium folding dynamic...
Henrietta Volkova· Zenodo (CERN European Organi...· 0 citations
Due to rising drug resistance, novel therapeutics are needed to combat the causative agent of malaria, Plasmodium spp.. Aspartic protease inhibition has emerged as a promising frontier for anti-malarial development as P. falciparum expresses five essential aspartic proteases in its symptomatic erythrocytic stages. Thes...
Katherine Floyd· Washington University in St....· 0 citations
A short procedure for assembling Cas9 RNPs with in vitro-transcribed guide RNAs is provided, making the protocol directly applicable to CRISPR RNP delivery in mammalian cells.
M. Skrbinek, Jure Bohinc· Methods in molecular biology· 0 citations
Dogs with PCC exhibit a distinct circulating protein signature vs healthy controls, providing clues to PCC pathogenesis and nominating proteins as diagnostic biomarker candidates and potential therapeutic targets.
Marit F. van den Berg, A. Rodríguez-Rojas, P. Doulidis et al.· Journal of Veterinary Intern...· 0 citations
MT-ProtBERT consistently outperforms PARROT, an RNN-based IDP-specific model, across all tasks, and demonstrates that combining self-supervised and biochemistry-informed tasks, and multi-scale learning enables robust modeling of unstructured proteins under data scarcity.
Jian Sun, Kingshuk Ghosh, Lilianna Houston et al.· 0 citations
A new machine-learning framework aims to improve the success rate of computational protein design while moving away from results that reproduce sequences found in nature.
