Elevated levels of the pro-inflammatory cytokine Interleukin 21 (IL-21) contribute to the progression of autoimmune and inflammatory diseases by binding to its receptor (IL-21R) and activating detrimental signaling pathways in immune cells. Consequently, we developed a recombinant decoy receptor protein designed to com...
Sara Vazifeshenas, Z. Hajihassan, Seyed Shahriar Arab et al.· Journal of Biomolecular Stru...· 0 citations
The findings suggest that 0.8 M HFIP and 3 M TFE stabilize structurally distinct molten globule-like intermediates of lysozyme at pH 2 and provide insight into early molecular events associated with protein aggregation.
The soluble expression of EKL in E. coli is achieved and a highly active mutant is obtained, and a visual tool for the rapid detection of EKL activity is provided.
Chang-Chun Han, Jun-Hao Yue, Yuwen Tu et al.· Sheng wu gong cheng xue bao...· 0 citations
This review systematically elaborates on the core components of the YSD microenvironment, including the cell wall, anchor proteins, intracellular secretion pathways, and extracellular physicochemical properties, and clarifies their critical roles in the folding, activity, and anchoring efficiency of displayed proteins.
Xin Luo, Wei-Jie Cao, Jing Yang et al.· Sheng wu gong cheng xue bao...· 0 citations
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Autoantibodies against tumor‐associated autoantigens are clinically valuable biomarkers for cancer diagnosis; however, the structural determinants governing epitope selectivity remain unknown. Here, we investigated whether the intrinsic conformational stability of target autoantigens regulates the epitope propensity of...
Ai Miyamoto, Rika Yamamoto, Ryui Sakaguchi et al.· Protein Science· 0 citations
Lower admission CALLY was independently associated with CA-AKI and showed moderate discriminatory ability and Prospective multicenter studies are needed to validate these findings and establish clinical utility.
Emre Eynel, D. Yılmaz, Arslan Nyyazov et al.· Medicina· 0 citations
Protein folding is highly sensitive to environmental conditions such as pH, which can influence internal hydrogen bonding and interactions with the solvent, and it is found that pH can shift proteins into or out of the two-state range of k2 values.
Knarik Yeritsyan, V. Uversky, A. Badasyan· Biomolecules· 0 citations
Abstract An increasing amount of attention has been directed towards beneficial microorganisms capable of producing bioactive substances, which can promote the growth of crops and enhance their defense mechanisms. This study focused on the growth-promoting effects of Bacillus velezensis HE-23, isolated from the roots o...
W. Jian, Y. Qin, Y. Chen et al.· Russian journal of plant phy...· 0 citations
The Big Fantastic Virus Database v3 is the most comprehensive resource for ColabFold-AlphaFold2-predicted viral protein structures, bringing us closer to a structural catalog of the known virosphere and is freely available at bfvd.workers.dev and bfvd.foldseek.com.
R. Kim, O. Pimenova, E. L. Karin et al.· bioRxiv· 0 citations
This review synthesizes the current design principles governing mRNA-DNA hybrid origami assembly, including helicity adjustment, crossover geometry and folding condition optimization, and examines the structural requirements for translational competence.
Eeva Enlund, Carmine D'Amico, Sharon Saarinen et al.· Current Opinion in Chemical...· 0 citations
The case of a 78-y-old man with previously treated high-risk PCa who developed biochemical recurrence is presented, where [68Ga]Ga-PSMA-11 PET/CT demonstrated tumor spread along sacral nerve roots and the sciatic nerve, suggestive of perineural invasion.
S. M. Gill, Fatima Yousaf, Mairah Razi et al.· Journal of Nuclear Medicine...· 0 citations
It is hypothesize that the RNA world was, actually, an ‘RNA-peptide world’, in which, from the earliest stages of evolution, evolving RNA molecules interacted with short random peptides synthesized in a non-templated manner, which could drive the evolution of diverse RNA structures and activities, and eventually, of th...
Harutyun Sahakyan, Y. Wolf, E. Koonin· bioRxiv· 0 citations
A new machine-learning framework aims to improve the success rate of computational protein design while moving away from results that reproduce sequences found in nature.
