Abstract The recombinant expression of integral membrane proteins is notoriously challenging. One way to address this challenge is via computational genotype-to-phenotype models that determine how particular sequence features correlate with protein expression levels. However, the potential of such approaches is yet to...
Membranes highly enriched in nicotinic acetylcholine receptor from the electroplaque organ of Torpedo californica were studied using x-ray diffraction, electron microscopy, Fourier image analysis and biochemical techniques. High angle diffraction indicated that the receptor molecule contains 8 nm long alpha-helical str...
Michael W. Klymkowsky· Caltech Library· 0 citations
Transmembrane proteins participate in numerous cellular processes, but their investigation is complicated by the compositional complexity of biological membranes. In particular, G protein-coupled receptors, which represent targets for nearly 50% of pharmaceuticals, require well-defined model membrane systems for functi...
Izabella Brand, Maxmilian Skoda, Mr Patryk Bielski et al.· Science and Technology Facil...· 0 citations
Major depressive disorder (MDD) is a prevalent and complex mental disorder, with mitochondrial metabolism implicated in its pathophysiology. However, specific candidate genes linking mitochondrial metabolism to MDD remain unidentified. This study aimed to discover and preliminarily assess candidate genes through integr...
Lianyong Zou, Yongping Zhao, Chao Han et al.· BMC Psychiatry· 0 citations
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Introduction:
Lupus nephritis (LN) is molecularly heterogeneous, and transcriptomic comparisons of histological classes can be confounded by renal tissue compartment and repeated sampling of the same patient.
Materials and methods:
We reanalyzed GSE127797 to compare class IV with class V LN using 44 Affymetrix...
Ming-Jie Li, Tirupapuliyur Damodaran· Academia Molecular Biology a...· 0 citations
Initial public release of PeptideArena, a benchmark of de novo peptide-binder backbone templates for inverse-folding evaluation. Contents 353 two-chain peptide–receptor PDB complexes 12 protein targets Peptide backbone lengths of 8, 16, and 24 residues Chain A: backbone-only poly-glycine designed peptide Chain B: fixed...
David Earl Hostallero, Glenn Butterfoss, Aron Broom et al.· Zenodo (CERN European Organi...· 0 citations
The bat-derived Pipistrellus bat coronavirus BtHKU5-CoV-2, a merbecovirus lineage, is an emerging zoonotic risk due to its ability to utilize human ACE2 receptors and ongoing spike protein recombination events that enhance cross-species transmission potential. At the moment no authorized vaccines are available against...
Amyloid plaques contain numerous proteins in addition to amyloid beta in Alzheimer’s disease (AD). Previous localized proteomics identified plaque-associated proteins in late-onset AD, early-onset AD, rapidly progressive AD, preclinical AD, and AD in Down syndrome, although most studies had smaller cohorts and focused...
Dominique Leitner, Evgeny Kanshin, Kaleah Balcomb et al.· Alzheimer s Research & Thera...· 0 citations
CS-Ole-Lip is supported as a stable oral nanocarrier with enhanced anti-inflammatory pharmacodynamic activity and the mechanistic basis for the dose-sparing effect requires direct pharmacokinetic and molecular validation.
Roi Martin B. Pajimna, John Wilfred T. Malabanan, Nonthaneth Nalinratana et al.· ACS Omega· 0 citations
Ascites, the pathological accumulation of fluid in the peritoneal cavity, is common at diagnosis and with recurrence in high-grade serous ovarian carcinoma (HGSOC). Higher volumes of ascites fluid are associated with greater likelihood of recurrent disease and poor prognosis. Due to its availability-volume and frequenc...
The molecular profile of donor kidneys is extensively remodeled during NMP, creating an ex vivo state that diverges considerably from in vivo physiology, challenging the use of in vivo biomarkers for ex vivo assessment.
V. Lantinga, Y. Zuo, C. Jaynes et al.· Kidney International· 0 citations
It is demonstrated that MMP-13 is overexpressed in canine mammary carcinomas and suggested that MMP-13 protein has the potential to serve as an additional candidate biomarker for the detection of canine mammary carcinomas.
Mamta Pandey, B. V. Sunil Kumar, Dipak Deka et al.· Protein Expression and Purif...· 0 citations
A new machine-learning framework aims to improve the success rate of computational protein design while moving away from results that reproduce sequences found in nature.
