Photocurable recombinant proteins and engineered polypeptides offer sequence-level control that is unavailable in most natural extracts or synthetic polymers. That control is meaningful only if molecular identity, folding state, functionalisation and network formation remain traceable through processing. Chemical modif...
Juan Segurola· Zenodo (CERN European Organi...· 0 citations
It is said that when the liver weakens, drugs act too strongly. What this paper shows is that the same change in the liver acts differently on an injection and on a pill, and that for a drug the liver removes almost completely (high extraction ratio) the injection is governed by liver blood flow and the pill by the liv...
Yuuki Yamagishi· Zenodo (CERN European Organi...· 0 citations
Structural analyses indicated that OsFe2200 adopts a putative Kelch β-propeller-like fold, while additional structural comparisons identified β-propeller- and Kelch-like proteins as moderate confidence homologs, suggesting that OsFe2200 is a structurally conserved but sequence divergent protein.
Reversible covalent targeting of cysteine residues offers a powerful strategy for generating potent and tunable ligands, but designing electrophiles with balanced reactivity, stability, and reversible binding remains challenging. Here, we systematically optimized reversible α,β-unsaturated nitrile electrophiles and i...
Yu-Qian Zhang, Meng-Zhu Qi, Xian-Kai Liu et al.· Journal of the American Chem...· 0 citations
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Honey bees (Apis mellifera) are highly sensitive to environmental stressors, including gamma radiation. We evaluated the biochemical responses of adult worker bees to graded gamma-irradiation doses (20, 30, 40 and 50 rad). Total soluble protein content and the activities of key enzymes; superoxide dismutase (SOD), cata...
Mohamed M. Abdel-Monsef, Sameh G. Sawires, Doaa A. Darwish· Entomological News· 0 citations
Protein folding is a process in which the linear amino acid chain is transformed into a stable three-dimensional native structure which enables the protein to carry out its function. In several neurodegenerative diseases, including Alzheimer's disease (amyloid-β) and Huntington's disease (huntingtin), a pathological me...
Yi-Yuan Xie· Theoretical and Natural Scie...· 0 citations
This work proves equivalence to the dense recurrence in real arithmetic, under an explicit scalar branch-interface assumption, and applies candidate sparsification to the multiloop recurrence of a Turner~2004 dangle-0 solver over a weighted codon automaton.
Carbapenem-resistant
Acinetobacter baumannii
is a hospital-associated pathogen linked to high mortality and limited treatment options. Although many resistance determinants have been identified, how they organize into coordinated systems remains unclear.
Using a final binary modeling dataset of 2,448 g...
Irfan Sharif Shaik, Morteza Sarmadi· Frontiers in Bioinformatics· 0 citations
Successive genome improvements reveal that while AP5292 and AP143 remain conserved, AP1260 and especially AP10948 have expanded into highly divergent multi-haplotype families, with AP10948 now comprising 25 tandemly duplicated variants.
J. V. Sullivan, M. Currie, P. J. Prendergast et al.· Australasian Plant Pathology· 0 citations
Deep learning-based protein design is used to generate de novo binders capturing this region of α-synuclein in a β-strand conformation to establish a set of molecules that target distinct aggregation intermediates and mechanistically reshape αSyn assembly.
Yun-Xuan Zhang, Hannah L. Han, L. Ortigosa-Pascual et al.· bioRxiv· 0 citations
Over the last decades, transformative catalytic strategies have emerged, with biocatalysis currently exerting a substantial influence on the pharmaceutical and fine chemical sectors. Fast progress in the design of efficient enzymatic processes, however, suffers from the lack of readily available, stable, and customizab...
Wael Elaily, David Stoll, Morakot Chakatok et al.· bioRxiv· 3 citations
Andrographolide (AG) has been reported for its anticancer activity. However, it is classified as a class IV in the biopharmaceutics classification system (BCS). Therefore, AG possesses low bioavailability due to its low solubility and permeability. In this study, hyaluronic acid-coated chitosan nanoparticles (Hyalo-CS-...
Sohaila A. Shoala, H. Abbas, H. Elbedaiwy et al.· European journal of pharmace...· 0 citations
A new machine-learning framework aims to improve the success rate of computational protein design while moving away from results that reproduce sequences found in nature.
