Background and Aim: Considering the role of exercise in controlling Diabetes and its complications and the lack of clarity on the molecular mechanism affecting Diabetes, the aim of the present study was to compare the effectiveness of two types of high- intensity interval training and continuous endurance training on t...
Proton-transfer reaction (PTR) has emerged as a powerful tool for top-down proteomics. It can mitigate spectral congestion and improve the signal-to-noise ratio of electrospray ionization (ESI)-generated intact proteins. We hypothesized that charge removal during PTR of Coulombically unfolded, denatured ESI ions indu...
Marek Polák, Lissa C. Anderson, Kristina Håkansson et al.· Analytical Chemistry· 0 citations
A mutational analysis of yeast RNA-binding protein Ssd1 is undertook to better understand domains and processes required for tolerating extra chromosomes, a special class of aneuploidy, and discusses implications for Ssd1 function and its role in aneuploidy tolerance in yeast.
Adam Jochem, Jamie M. Ahrens, Emma Mayhew et al.· bioRxiv· 0 citations
Background/Objectives: We compared next-morning fecal metabolic and microbial responses to five acute fueling strategies. Methods: Eight male recreational rowers with complete specimens from 12 crossover completers received an erythritol comparator, two carbohydrate doses, fixed carbohydrate–protein, and personalized c...
The reproducibility of these effects across ten geographically distinct state populations establishes a state-level baseline for SARS-CoV-2 immune escape, and establishes a state-level baseline for SARS-CoV-2 immune escape.
Som V. Thomas, Jing Chen, D. Qian et al.· Bioengineering· 0 citations
An isotope-labeling method using mammalian cells for high-sensitivity NMR studies of membrane proteins and their complexes and enables the NMR detection of the human membrane protein complex CD19-CD81, an essential co-receptor in B-cell activation, validating their stable interaction.
Taiga Yamamoto, Yutaka Kofuku, Yutaro Ogaeri et al.· Journal of the American Chem...· 0 citations
Resveratrol enhances MTX’s anti-inflammatory effects via dual inhibition of NF-κB and MAPK pathways, while reducing MTX-induced toxicity, and support the potential of MTX-resveratrol co-therapy as a safer, more effective strategy for managing chronic inflammatory diseases.
Mashael J. Abu-Alola, Moonerah M. Alnasser, A. Al-Qahtani et al.· Journal of King Saud Univers...· 0 citations
The RNA recognition motif (RRM) domain of TAF15 protein plays an essential role in RNA binding and regulation of diverse cellular processes. However, the molecular mechanism underlying its structural stability and folding behaviour associated with disease state remains poorly understood. Herein, we performed an extensi...
Photocurable recombinant proteins and engineered polypeptides offer sequence-level control that is unavailable in most natural extracts or synthetic polymers. That control is meaningful only if molecular identity, folding state, functionalisation and network formation remain traceable through processing. Chemical modif...
Juan Segurola· Zenodo (CERN European Organi...· 0 citations
It is proposed that TMEM263 can interact with and support the condensation of neutral lipids in a bilayer to promote lipid droplet formation and growth and provide a mechanistic understanding linking these phenotypes to impaired lipid droplet biology.
Katy Yalci, N. Chala, Joanna J. Moss et al.· Nature Communications· 0 citations
This paper presents a complete symbolic proof of the Collatz Conjecture using the Expansion–Compaction–Torsion (ECT) model. By interpreting the iterative Collatz function as a symbolic parity-driven oscillator, the authors define a torsion-based energy function δ(n) that tracks the expansion (odd steps) and compaction...
Andrew Robert Hutchins, Helen Christina Hutchins, Nova Freeman Wells· Zenodo (CERN European Organi...· 0 citations
Photocurable recombinant proteins and engineered polypeptides offer sequence-level control that is unavailable in most natural extracts or synthetic polymers. That control is meaningful only if molecular identity, folding state, functionalisation and network formation remain traceable through processing. Chemical modif...
Juan Segurola· Zenodo (CERN European Organi...· 0 citations
A new machine-learning framework aims to improve the success rate of computational protein design while moving away from results that reproduce sequences found in nature.
