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1,913 papers
Overall, these findings support an effect of the five variants on α-galactosidase A structure and function and highlight the value of integrating clinical, genetic, biochemical, and computational data for variant interpretation.
Apolipoprotein E (ApoE) performs most of its pathologically relevant biology at lipid interfaces, yet design efforts target its receptor binding, interdomain geometry or abundance rather than the lipid affinity of its N-terminal bundle. We asked whether the reverse-QTY (rQTY) code can make that bundle membrane-compatib...
The RNA recognition motif (RRM) domain of TAF15 protein plays an essential role in RNA binding and regulation of diverse cellular processes. However, the molecular mechanism underlying its structural stability and folding behaviour associated with disease state remains poorly understood. Herein, we performed an extensi...
Background. Alternative oxidase (AOX) is a mitochondrial terminal oxidase that provides an alternative route for electron transfer, contributing to respiratory flexibility and redox homeostasis under stress conditions. In trypanosomatids, AOX displays a highly uneven distribution associated with extensive diversificati...
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To investigate the association of C-reactive protein to albumin ratio (CAR) with sarcopenia and to evaluate its discriminative performance in patients with type 2 diabetes mellitus (T2DM). We enrolled 265 patients with T2DM within this single-center, retrospective study. Sarcopenia was diagnosed according to the 2019 A...
Pathview visualizations of significantly enriched KEGG pathways across directional cowpea comparisons: The ZIP archive contains pathway maps for KEGG comparison-direction contexts that meet the enrichment threshold (FDR < 0.05). Protein log₂ fold-change values are overlaid on pathway nodes to illustrate the direction a...
The calories on a food label are taken to be heat measured by burning. What this paper shows is that they are an estimate, by conversion factors, of what the body can extract, and that the gap from the heat of combustion gathers almost entirely in protein. No new theorem or law is claimed. Scope of this paper (scope no...
It is said that when the liver weakens, drugs act too strongly. What this paper shows is that the same change in the liver acts differently on an injection and on a pill, and that for a drug the liver removes almost completely (high extraction ratio) the injection is governed by liver blood flow and the pill by the liv...
These results establish that probability encoding, storage, and Bayesian inference can be physically unified in a vertical memristive array, providing a compact hardware platform for parallel Bayesian computing.
Interferon gamma (IFN-γ) is a potent cytokine secreted following primary varicella-zoster virus (VZV) infection. Our previous studies demonstrated that pretreatment with IFN-γ completely inhibited VZV replication in lung fibroblast MRC-5 and retinal epithelial ARPE-19 but not in melanoma MeWo cells, suggesting that IFN...
Hydrogen/Deuterium eXchange (HDX) methods for studying protein dynamics would benefit from millisecond-scale incubations to probe intrinsically disordered proteins, highly dynamic regions, and conformation changes. Here, we investigate droplet microfluidics for rapid mixing to trigger D2O labeling, uniform incubation...
The risk of zoonotic spillover of coronaviruses poses a constant threat to humanity, as recently exemplified by SARS‑CoV-2. During the pandemic, the rapid emergence of immune escape mutations led to a loss of efficacy of both therapeutic and humoral anti‑spike antibodies, emphasizing the need for therapeutics that enga...
Proof of concept for watermarking AI-generated proteins while preserving biological function.
A new machine-learning framework aims to improve the success rate of computational protein design while moving away from results that reproduce sequences found in nature.
Scientists are using AlphaFold to strengthen a photosynthesis enzyme for resilient, heat-tolerant crops.
Explore how AlphaFold has accelerated science and fueled a global wave of biological discovery.
AlphaFold has revealed the structure of a key protein behind heart disease
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