This is a Perspective article. Two recent Cell studies (Dobbs et al., 2026; Jensen et al., 2026) used in-cell cryo-electron tomography and visual proteomics in Mycoplasma pneumoniae to resolve structural coordination among transcription, translation, membrane translocation, and extracellular folding.We offer a theoreti...
Hongkui Liu, Kai Huang, Ziwei Huang· Zenodo (CERN European Organi...· 0 citations
The calories on a food label are taken to be heat measured by burning. What this paper shows is that they are an estimate, by conversion factors, of what the body can extract, and that the gap from the heat of combustion gathers almost entirely in protein. No new theorem or law is claimed. Scope of this paper (scope no...
Yuuki Yamagishi· Zenodo (CERN European Organi...· 0 citations
Bacterial keratitis is a common condition that can result in serious complications including vision impairment and loss of the eye if not treated aggressively. Topical blood products are often utilized concurrently with topical antibiotics for their known anti-collagenolytic properties. These blood products contain a...
Helen O. Kim, M. A. Kubai, Levi Brock et al.· Frontiers in Veterinary Scie...· 0 citations
Microtubules constitute fundamental cytoskeletal polymers that orchestrate cell division, intracellular trafficking, and the maintenance of cellular architecture across eukaryotic lineages. The biogenesis, folding, and steady-state homeostasis of αβ-tubulin heterodimers are tightly regulated by an evolutionarily conser...
Protein-primed Replication for In vivo Mutagenesis and Evolution, a plasmid-based orthogonal DNA replication system for continuous directed evolution in Escherichia coli, provides a broadly accessible framework for continuous in vivo evolution, with wide-ranging applications in protein engineering and synthetic biology...
Erik Dechant, Lena K. Träger, S. Sikanjic et al.· bioRxiv· 0 citations
Background and Aim: Considering the role of exercise in controlling Diabetes and its complications and the lack of clarity on the molecular mechanism affecting Diabetes, the aim of the present study was to compare the effectiveness of two types of high- intensity interval training and continuous endurance training on t...
Proton-transfer reaction (PTR) has emerged as a powerful tool for top-down proteomics. It can mitigate spectral congestion and improve the signal-to-noise ratio of electrospray ionization (ESI)-generated intact proteins. We hypothesized that charge removal during PTR of Coulombically unfolded, denatured ESI ions indu...
Marek Polák, Lissa C. Anderson, Kristina Håkansson et al.· Analytical Chemistry· 0 citations
A mutational analysis of yeast RNA-binding protein Ssd1 is undertook to better understand domains and processes required for tolerating extra chromosomes, a special class of aneuploidy, and discusses implications for Ssd1 function and its role in aneuploidy tolerance in yeast.
Adam Jochem, Jamie M. Ahrens, Emma Mayhew et al.· bioRxiv· 0 citations
Background/Objectives: We compared next-morning fecal metabolic and microbial responses to five acute fueling strategies. Methods: Eight male recreational rowers with complete specimens from 12 crossover completers received an erythritol comparator, two carbohydrate doses, fixed carbohydrate–protein, and personalized c...
The reproducibility of these effects across ten geographically distinct state populations establishes a state-level baseline for SARS-CoV-2 immune escape, and establishes a state-level baseline for SARS-CoV-2 immune escape.
Som V. Thomas, Jing Chen, D. Qian et al.· Bioengineering· 0 citations
An isotope-labeling method using mammalian cells for high-sensitivity NMR studies of membrane proteins and their complexes and enables the NMR detection of the human membrane protein complex CD19-CD81, an essential co-receptor in B-cell activation, validating their stable interaction.
Taiga Yamamoto, Yutaka Kofuku, Yutaro Ogaeri et al.· Journal of the American Chem...· 0 citations
Resveratrol enhances MTX’s anti-inflammatory effects via dual inhibition of NF-κB and MAPK pathways, while reducing MTX-induced toxicity, and support the potential of MTX-resveratrol co-therapy as a safer, more effective strategy for managing chronic inflammatory diseases.
Mashael J. Abu-Alola, Moonerah M. Alnasser, A. Al-Qahtani et al.· Journal of King Saud Univers...· 0 citations
A new machine-learning framework aims to improve the success rate of computational protein design while moving away from results that reproduce sequences found in nature.
