Biological systems often regulate catalysis by organizing enzymes within dense, multivalent, and nanostructured environments. Nanomaterials can recreate selected features of these environments, but their effects on enzymes range from inhibition to activity enhancement depending on the chemistry of their surface ligands...
Gabriel Gilman, Atri Bhattacharya, Niloufar Yavari et al.· ACS Applied Materials and In...· 0 citations
Zenodo data README This dataset contains data files and experimental results associated with the manuscript "Uncertainty-aware benchmarking reveals ambiguous transcripts in mRNA–lncRNA classification". Related Code Repository: https://github.com/cbib/uncertainty_aware_lnclassifier Data Archive DOI: 10.5281/zenodo.19551...
Daniel García‐Ruano, Mikaël Georges, Saswat K. Mohanty et al.· Zenodo (CERN European Organi...· 0 citations
A bstract Proteins are built from 20 canonical amino acids. It is interesting to explore whether proteins can be formed from significantly reduced amino acid alphabets. Our bioinformatics survey of UniProt (more than 250 M sequences) revealed that proteins composed of reduced amino acid alphabets (< 10) are extremely r...
Karel Půbal, Kseniia Kushnir, Vojtěch Spiwok et al.· FEBS Journal· 0 citations
Medium-chain fatty acids (MCFAs) offer a sustainable route for valorizing waste-activated sludge (WAS) into higher-value products, yet their bioproduction is constrained by the rigid extracellular polymeric substance (EPS) barrier and inefficient chain elongation (CE). Here, we develop a synergistic pretreatment stra...
Ya Ji, Xiao-Feng Luo, Qing-Yu Zhao et al.· ACS ES&T Engineering· 0 citations
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CAmp-scWB, a post-separation amplification strategy that performs rolling-circle amplification directly within the polyacrylamide gel after single-cell protein electrophoresis, enables proteoform-resolved analysis of heterogeneous cells and small extracellular vesicles.
Lu-Yao Zhao, Yan-Jun Yang, Yao-Chao Zheng et al.· 0 citations
NLGs are a hybrid phospholipid-polymer carrier built around a synthetic phospholipid, phosphatidylbutenol synthesised in a single enzyme-catalysed transphosphatidylation step from 1,2-dioleoyl-sn-glycero-3-phosphocholine, and exhibit sustained mRNA release over seven days in the presence of 10 mM glutathione.
Ellen Oudkerk-Sodia, Run-Xin Xu, Renee Chu et al.· RSC Advances· 0 citations
Study objectives were to determine the effects of a dietary clay mineral-based feed additive on performance, metabolism, inflammation, and liver and gastrointestinal health in acutely heat-stressed lactating dairy cows. Primiparous Holstein cows (148 ± 25 DIM; 600 ± 50 kg BW; n = 12) were balanced by DIM and milk yield...
S. Rodriguez-Jimenez, J. Opgenorth, E. J. Mayorga et al.· Journal of Dairy Science· 0 citations
A network pharmacology analysis of compound 4d against pancreatic cancer identified 243 shared targets that converged, through protein-protein interactions and enrichment analyses, on the PI3K-AKT and receptor tyrosine kinase signalling axes, providing a system-level rationale for its anticancer potential.
S. Ejaz, M. Bilal, P. Channar et al.· RSC Advances· 0 citations
Overall, this study provides a clear innovative-driven SAR model for bis-imine-based Glo-I inhibitors and identified compound 8a as an optimized lead for the future design of anticancer candidates targeting Glo-I enzyme.
Buthina A. Al-Oudat, Farah B. Al-Omari, S. A. Audat et al.· Medicinal Chemistry Research· 0 citations
Pathview visualizations of significantly enriched KEGG pathways across directional cowpea comparisons: The ZIP archive contains pathway maps for KEGG comparison-direction contexts that meet the enrichment threshold (FDR < 0.05). Protein log₂ fold-change values are overlaid on pathway nodes to illustrate the direction a...
Glyphosate, the most widely used herbicide worldwide, has experienced a more than 12-fold increase in application over the past decade, raising substantial public health concerns regarding its potential reproductive toxicity. Previous toxicological studies have primarily focused on the effects of high-dose exposures,...
Jin-Fa Zheng, Ling Yu, Shu-Lan Li et al.· Chemical Research in Toxicol...· 0 citations
Pre-existing anti-diphtheria toxoid IgG measured before vaccination was not associated with a consistent reduction in post-primary serotype-specific pneumococcal IgG responses to CRM197-conjugated BE-PCV14, and analyses stratified by baseline pneumococcal IgG similarly showed no consistent evidence of reduced responses...
S. Thuluva, S. Gunneri, S. Ningaiah et al.· Vaccines· 0 citations
A new machine-learning framework aims to improve the success rate of computational protein design while moving away from results that reproduce sequences found in nature.
