protein folding

A chromosome-level genome of the king penguin (Aptenodytes patagonicus): a resource for linking genotype to fitness in a long-lived vertebrate

This genome provides a foundation for ongoing and future studies using the king penguin to investigate genotype–fitness relationships, ageing, life-history evolution, and adaptation, exceeding the standards of the Earth BioGenome Project and Vertebrate Genomes Project.

Policy Drift in Learning AI Agents: A Dynamical Systems Perspective on Security Degradation

Policy drift takes shape through a nonlinear differential equation - framed within the policy state space - with support from Lyapunov stability concepts alongside bifurcation methods alongside bifurcation methods, and the Intent Drift Rate appears: a concrete number per dialogue turn built as the time-based change in...

Intent-Based Security: Replacing Identity-Centric Trust in Autonomous AI Agentic Systems

Intent-Based Security (IBS), a structured approach built on foundational ideas from access control, zero-trust models, and principal-agent dynamics, shows why trusting identities fails against invisible threats.

From Chain-of-Note to Explainable Cognitive Prompting: Reproducible Multi-Layer Validation for Auditable LLM-Assisted PLC Programming : Structured Explainability and Deterministic Reasoning for Industrial PLC Applications

Explainability in Large Language Model (LLM)–assisted PLC programming is essential for industrial adoption, where engineers must understand, validate, and maintain generated control logic under strict safety and standardization constraints. Existing explainability-oriented prompting approaches such as Chain of Note (Co...

Does Scientific Explanation Depend on Narrative Coherence?

This paper critically examines the long-standing question of whether scientific explanation depends on narrative coherence. While traditional philosophy of science has largely marginalized the role of narrative, this paper argues that narrative coherence is not merely a rhetorical or pedagogical tool, but a fundamental...

Does Scientific Explanation Depend on Narrative Coherence?

This paper critically examines the long-standing question of whether scientific explanation depends on narrative coherence. While traditional philosophy of science has largely marginalized the role of narrative, this paper argues that narrative coherence is not merely a rhetorical or pedagogical tool, but a fundamental...

The Synthetic Consensus Trap: Correlated AI Errors, Verification Overload, and the Mathematics of Institutional Epistemic Cascades

Institutions are beginning to use multiple large language models, AI agents, automated reviewers, and human overseers as if agreement among them were independent corroboration. That assumption can fail. This paper develops the Synthetic Consensus Cascade (SCC) framework, a multidisciplinary mathematical model linking c...

The Synthetic Consensus Trap: Correlated AI Errors, Verification Overload, and the Mathematics of Institutional Epistemic Cascades

Institutions are beginning to use multiple large language models, AI agents, automated reviewers, and human overseers as if agreement among them were independent corroboration. That assumption can fail. This paper develops the Synthetic Consensus Cascade (SCC) framework, a multidisciplinary mathematical model linking c...

Differential expression results for behavioural profile and mitochondrial lineage in Salamandra salamandra larvae

This dataset contains the complete annotated differential-expression results used in the study “Transcriptomic correlates of dispersal-related behavioural profiles in Salamandra salamandra larvae across a mitochondrial contact zone”.Differential expression was analysed at the Corset-cluster level using RNA-seq data fro...

Session 5: Proteostasis Mechanisms: Protein Folding and Degradation (joint session)

Spatial Statistics and Explainable Deep Learning for 3D Cell–Protein Interaction Profiling

Digital histology of human postmortem brain tissue is fundamental to understanding neurodegeneration, yet resolving the spatial organisation of neuroinflammatory markers remains challenging because manual scoring and scalar summaries capture only part of the image information. We present a dual-tiered computational fra...

THE EFFECT OF PROBIOTIC USE ON THE DIGESTIVE PROCESSES AND PRODUCT QUALITY OF BROILER CHICKENS

The purpose of the study is to provide a scientific substantiation and experimental evaluation of the effectiveness of Sub–Pro probiotic application to increase productivity, improve feed conversion and biological usefulness of meat from Cobb 500 cross broiler chickens in industrial cultivation. The experiment was cond...