Safe, efficient gene delivery throughout the CNS remains a central obstacle to treating genetic diseases of the brain and spinal cord. We describe BI-TfR1 CapX, a human transferrin receptor (TfR1)-binding AAV capsid that, after a low intravenous dose in adult humanized TFRC mice, transduced more than 80% of cortical an...
Ken Y. Chan, Chin-Yen Lin, Qin Huang et al.· bioRxiv (Cold Spring Harbor...· 0 citations
This repository includes a theoretical extension of the General Epistemic Dispersion Theory (GEDT) formalism to the domain of molecular biology, using adult human hemoglobin (HbA) as a case study. The manuscript proposes a bio-epistemic mapping in which the acquisition of the three-dimensional configuration is analyzed...
Massimo Comitato· Zenodo (CERN European Organi...· 0 citations
Using the 240 E8 root vectors as a dynamic phase‑modulation scaffold, we demonstrate that phi‑coupled 132 Hz inputs can generate a self‑synchronizing attractor field that links quantum superposition lifetimes to neural oscillation phases. This field produces a stable interference pattern that simultaneously modulates p...
Andrew Stewart Caldin· Zenodo (CERN European Organi...· 0 citations
Zenodo data README This dataset contains data files and experimental results associated with the manuscript "Uncertainty-aware benchmarking reveals ambiguous transcripts in mRNA–lncRNA classification". Related Code Repository: https://github.com/cbib/uncertainty_aware_lnclassifier Data Archive DOI: 10.5281/zenodo.19551...
Daniel García‐Ruano, Mikaël Georges, Saswat K. Mohanty et al.· Zenodo (CERN European Organi...· 0 citations
Reach audiences
Advertise in front of researchers, engineers, and readers.
This academic curriculum module delivers an analytical, biophysical, and computational exposition of bioinformatics, computational genomics, sequence alignment algorithms, structural biology, and high-throughput multi-omics data integration. Key Technical Topics & Curricular Areas Covered:1. Genomic Data Acquisition &...
Prep4Uni.Online· Zenodo (CERN European Organi...· 0 citations
This academic curriculum module delivers an analytical, biophysical, and computational exposition of bioinformatics, computational genomics, sequence alignment algorithms, structural biology, and high-throughput multi-omics data integration. Key Technical Topics & Curricular Areas Covered:1. Genomic Data Acquisition &...
Prep4Uni.Online· Zenodo (CERN European Organi...· 0 citations
Motivation. Predicted-structure databases have made it routine to ask what fraction of a proteome adopts a fold with no known relative. Reported novelty rates vary widely between studies, and it is unclear how much of that variation is biological rather than methodological. A novelty call is a negative result, so it in...
Khan Osman· Zenodo (CERN European Organi...· 0 citations
Structural models of the quaternary complex comprising the heterotrimeric PP2A holoenzyme and the phosphorylated Parkin Ubl domain were generated using AlphaFold3. The modeled protein assembly included the catalytic subunit Cα (PP2Ac, Uniprot: P67775), the scaffolding subunit PR65A (residues 1–589, Uniprot: P30153), th...
Chun Tang, Fuxiang Liang, Lingsen Meng· Zenodo (CERN European Organi...· 0 citations
This dataset provides paired transcriptomic (RNA-seq) and proteomic profiling of vascular smooth muscle cells (VSMCs) from pulmonary artery and aorta under hypertensive and normotensive conditions in rats, aiming to identify tissue-specific molecular responses to hypertension. Four groups (n=3 each): NPA (normal pulmon...
This work redefines the cell membrane beyond the classical fluid mosaic model into a coherent biophotonic network. Every membrane constituent—including lipids (PC, PE, PS, PI, SM, cholesterol), integral and peripheral proteins, ion channels, pumps, receptors, HLA molecules, glycocalyx, cytoskeleton, lipid rafts, and ex...
outail benhadid· Zenodo (CERN European Organi...· 0 citations
This study investigates the impact of social media on the development of communicative compensation strategies among Lung fibrosis, particularly idiopathic pulmonary fibrosis (IPF), involves chronic, progressive scarring of lung tissue driven by dysregulated extracellular matrix (ECM) remodelling and persistent fibrobl...
Sakshi Soni, Ruchi Yadav· The American Journal of Inte...· 0 citations
Cephalotaxine (1) is a parent compound within the cephalotaxine alkaloids class mainly derived from Cephalotaxus plants. In this study, by coupling 1 with cinnamic acid, 17 novel cephalotaxine-cinnamic acid derivatives (S1–S17) were designed and synthesized to enhance their anti-tumor efficacy. Among them, S10 showed t...
Wenxing Li, Yiming Qian, Hao Wang et al.· Molecules· 0 citations
A new machine-learning framework aims to improve the success rate of computational protein design while moving away from results that reproduce sequences found in nature.
