AI Networking Cookbook: Practical recipes for AI-assisted network automation and development
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2,052 papers
The crystal structure of AcrIIA17 is presented and its mechanism of Staphylococcus aureus Cas9 (SauCas9) inhibition is elucidated, identifying AcrIIA17 as an Acr protein that targets the Cas9 BH domain and reveal the BH domain as a regulatory checkpoint in Cas9 activation.
The metabolic phenotypes were explored in a primary care T2DM cohort, supporting their reproducibility across clinical settings and vitamin D status varied by phenotype severity, with more severe phenotypes more likely to exhibit insufficiency.
BgtH12 is established as a critical virulence factor that suppresses basal immunity to promote Bgt colonization and stable overexpression of BgtH12 in wheat enhanced susceptibility.
This case highlights the importance of continued endoscopic surveillance for gastric carcinogenesis even after long‐term clinical remission of MD and reveals no evidence of active MD.
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Findings demonstrates that optimized pretreatment coupled with selected indigenous bacterial isolates enhanced conversion of WB into protein-enriched microbial biomass, providing a basis for further development of lignocellulosic biomass valorization for SCP production.
Two orthogonal systems for inducible transcriptional repression in the malaria parasite Plasmodium falciparum using bacterial repressor proteins are created, improving on previous attempts at transcriptional regulation by two orders of magnitude and outperforming gold standard translational/post-transcriptional regulat...
Prot-LAMBDA is introduced, a PLM that explicitly incorporates spatial relationships by coupling residue embeddings with inter-residue contacts and LambdaFold, a lightweight distance-guided structure prediction framework that achieves performance comparable to ESMFold on proteins strictly non-redundant to the training d...
The highly modular network restricted horizontal gene transfer of ARGs, mitigated the enrichment of pathogenic antibiotic-resistant bacteria (PARBs) and occurrence of high-risk ARGs in MMB-CW, providing an optimization strategy for MMB-CW in view of treatment performance and ecological risk.
The application of quercetin in functional foods is severely limited by its poor aqueous solubility, chemical instability, and low oral bioaccessibility. This study investigated the synergistic effects of ultrasound pretreatment and λ-carrageenan (λ-CA) complexation on the stability and quercetin delivery efficiency of...
Regulation of walnut fruit maturation is crucial for delaying harvest and maintaining kernel quality. In this study, 'Qingxiang' walnut (Juglans regia L.) fruit were treated with 300 mg L-1 gibberellic acid (GA3) during 20-100 days after flowering (DAF) to assess its effects on fruit development, kernel nutrient compos...
Abstract Commercial Bacillus-based probiotics are widely used in poultry production, but their biological mechanisms of action in broiler chickens are still not fully understood. This study evaluated the effects of dietary supplementation with Bacillus-based commercial probiotics on the performance, meat and tibia trai...
Nacre supplementation was associated with improved performance in the Y-maze and novel object recognition tests, reduced amyloid-β deposition and Congo red-positive plaque burden, lower phosphorylated tau immunoreactivity, and fewer histologically degenerated hippocampal neurons.
Proof of concept for watermarking AI-generated proteins while preserving biological function.
A new machine-learning framework aims to improve the success rate of computational protein design while moving away from results that reproduce sequences found in nature.
Scientists are using AlphaFold to strengthen a photosynthesis enzyme for resilient, heat-tolerant crops.
Explore how AlphaFold has accelerated science and fueled a global wave of biological discovery.
AlphaFold has revealed the structure of a key protein behind heart disease
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