Abstract Commercial Bacillus-based probiotics are widely used in poultry production, but their biological mechanisms of action in broiler chickens are still not fully understood. This study evaluated the effects of dietary supplementation with Bacillus-based commercial probiotics on the performance, meat and tibia trai...
V. Vu, Soo-Ki Kim, H. Bui et al.· Journal of Animal Science· 0 citations
Nacre supplementation was associated with improved performance in the Y-maze and novel object recognition tests, reduced amyloid-β deposition and Congo red-positive plaque burden, lower phosphorylated tau immunoreactivity, and fewer histologically degenerated hippocampal neurons.
Kanae Ohara, Heng Zhang, Hiroto Shibata et al.· Journal of Dietary Supplemen...· 0 citations
A unified view is provided of how genome structure is established, how it relates to function, and how its disruption contributes to tumorigenesis, suggesting that alterations in genome structure can, in some contexts, actively reshape oncogenic programs.
Rebecca G. Smith, Hannah M. Wilson, Kathleen L. Schiela et al.· Genes & Development· 0 citations
A comparative protein engineering strategy that integrates prior mutagenesis, bioinformatics, and structural insights to reprogram LC protease specificity is reported, establishing comparative protein engineering as an effective framework for retargeting botulinum neurotoxin proteases.
J. E. Garrido, G. S. Salcedo, Max W. Strul et al.· Cell Chemical Biology· 0 citations
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A framework that overcomes the internalization barrier, broadening the target scope for therapeutic and diagnostic conjugates is established and extended BTR to programmed cell death ligand 1 (PD-L1) and an mRNA-display-derived FAP peptide, suggesting potential broad applicability.
Zihao Wen, Mengxin Xu, Zi-Jun Yan et al.· Nature· 1 citation
Three commonly used types of neutralization assay were compared and strong correlations and significant differences in measured neutralization between the different assays were found, highlighting areas for more precise and harmonized terminology and particular assay elements that must be considered in efforts to harmo...
E. Stadler, F. Mordant, Matthew J. Gartner et al.· Journal of Virology· 0 citations
It is found that the MIC10 proteins Mic10, Mic26, and Mic27 strongly recruit cardiolipin at conserved positive loop motifs, driving oligomerization of these subunits and resulting in the stabilization of curvature in model membranes.
C. Brown, T. Wassenaar, Z. Freyberg et al.· Science Advances· 0 citations
AgentFold is presented, a multi-agent framework that formulates folding-model development as a closed-loop search over executable code variants and improves the best lDDT by 7.5% over independent Codex proposals and outperforms a random-search control.
Ming-Quan Liu, Jiangyue Chen, Han-Qun Cao et al.· 0 citations
This survey reviews the basic principles of LLMs and summarizes representative applications in gene and genome sequence analysis, protein structure and function prediction, and drug design, including virtual screening and personalized medicine.
Zhi-Gang Meng, Zhi-Kai Yang, Mingming Zhu et al.· Frontiers in Genetics· 0 citations
This study demonstrates the successful production and injection of human induced pluripotent stem cell cardiomyocyte aggregates into infarcted cynomolgus monkey hearts, resulting in substantial, structured human grafts three months after cell transplantation, and uncoupling of cardiomyocyte production from transplantat...
I. Gruh, Andreas Martens, S. Cebotari et al.· Nature Communications· 0 citations
A new machine-learning framework aims to improve the success rate of computational protein design while moving away from results that reproduce sequences found in nature.
