AI Networking Cookbook: Practical recipes for AI-assisted network automation and development
Category
2,052 papers
UshEffect-3D serves as an interpretable protein-specific framework and a supplementary ranked resource that can be used to flag unresolved variants for further clinical and experimental review.
A scalable technology is introduced that quantifies thousands of proteins and transcripts in the same cell, separating RNA from protein by tip-based C18 capture and pairing full-length RNA sequencing with latest-generation mass spectrometry to yield deep proteome and transcriptome from the same cells.
The results show that alternative transcript diversity extensively enters translation-supported proteoform space and establish a systematic link between transcript variation and protein functional diversification.
EvoPLM-Tree, a tree-aware conditional autoregressive language model that predicts descendant protein sequences from ancestral sequences together with phylogenetically derived evolutionary features, provides a framework for modeling protein evolution along phylogenetic lineages and prioritizing plausible future mutation...
Reach audiences
Advertise in front of researchers, engineers, and readers.
All-atom simulations with explicit solvent can provide a detailed and accurate description of dynamics and mechanisms in biomolecular systems, including intrinsically disordered proteins (IDPs) and their condensates. However, interactions involving charged residues and ions remain a persistent source of systematic erro...
This work demonstrates that necrotrophic pathogenesis in B. cinerea does not depend on a few primary virulence determinants, but rather on a highly redundant network of host damaging factors.
A large number of DHF proteins featuring a high or very high degree of identity with the amino acid sequences of both histones H3 and H4 are identified, which constitute a new class of eukaryotic DHF proteins.
Findings identify a novel PRDX1-PRMT5 axis that activates Wnt/β-catenin signaling, highlighting a potential therapeutic strategy for CRC by targeting this pathway to suppress tumor progression and remodel the immune microenvironment.
The solution structure of mature Saccharomyces cerevisiae Mba1 is determined using multidimensional nuclear magnetic resonance (NMR) spectroscopy and reveals a compact α + β fold with a central hydrophobic cavity and distinct charged surface regions, providing a structural framework for interpreting previous functional...
These findings demonstrate that the conformational plasticity of HOP can be strategically exploited for targeted protein-protein interaction (PPI) disruption in cancer therapy.
This study investigated the potential use of hemp seed oil-carnauba wax oleogel as a margarine substitute in crackers and the effects of substituting wheat flour with hemp seed flour. Characterization revealed that 11% wax oleogel best mimicked margarine. Control crackers contained margarine (C1) and oleogel (C2). Whea...
FPCct appears to act like a physiological suppressor of cystogenic signaling, as found in healthy kidney epithelia, that is essential for maintaining epithelial homeostasis.
Proof of concept for watermarking AI-generated proteins while preserving biological function.
A new machine-learning framework aims to improve the success rate of computational protein design while moving away from results that reproduce sequences found in nature.
Scientists are using AlphaFold to strengthen a photosynthesis enzyme for resilient, heat-tolerant crops.
Explore how AlphaFold has accelerated science and fueled a global wave of biological discovery.
AlphaFold has revealed the structure of a key protein behind heart disease
We use cookies to run the site and, with your consent, for analytics and to show ads. See our Cookie Policy.
