protein folding

The Mystery of the 10⁵ Temperature Gap Inside Cells: The Limits and Challenges of Nanothermometry

Researchers at Osaka University in Japan and the University of Queensland in Australia have published a review analysing the enormous gap between theory and measured values that confronts luminescence nanothermometry, the technique used to measure temperature inside cells. The authors argue that the concept of temperat...

Characterization of Cry2Ab2 resistance in Crocidosema sp. (Lepidoptera: Tortricidae): resistance selection, inheritance, cross-resistance patterns, and fitness costs.

Resistance to Cry2Ab2 in Crocidosema sp.

AI for Science: Reframing AI’s Role in Discovery

This paper explores how AI contributes to science, introducing a framework organised around task capabilities, scientific workflow integration, and domain constraints, and uses that framework to open wider questions about the role of AI in scientific discovery.

A conserved cysteine–histidine–glutamate metal site identifies DUF501 (Rv1025), an essential uncharacterised protein family of Mycobacterium tuberculosis, as a candidate metalloenzyme and drug target

It is proposed that DUF501 is a metal-binding protein and candidate metalloenzyme, the first functional hypothesis for this family, whose conserved, essential metal pocket is a promising drug target.

Quantum-Driven Constraint on Complex Systems

Quantum-driven constraint on complex systems aims to accelerate solution processes by dynamically adjusting constraint parameters. This paper explores the potential of quantum annealing and variational quantum eigensolver (VQE) to optimize these parameters. The core claim is to implement an algorithm that dynamically a...

The Mystery of the 10⁵ Temperature Gap Inside Cells: The Limits and Challenges of Nanothermometry

Researchers at Osaka University in Japan and the University of Queensland in Australia have published a review analysing the enormous gap between theory and measured values that confronts luminescence nanothermometry, the technique used to measure temperature inside cells. The authors argue that the concept of temperat...

Integrated Time-Series Biochemical, Transcriptomic and Metabolomic Analyses Reveal Key Pathways and Concentration-Dependent Transitions in Chironomid Larvae (Propsilocerus akamusi) Under Chlorantraniliprole Stress

Findings reveal the adaptive strategies of chironomids to cope with pesticide stress from the environment, and highlight the urgent need to protect these animals and their freshwater habitats from agricultural pollution.

Predicting Spatial Variability of PR Protein Concentration in White Grape Juice Using UAV Multispectral Data and Machine Learning

Background: Pathogenesis-related (PR) proteins, primarily thaumatin-like proteins (TLPs) and chitinases, are the principal cause of protein haze formation in white wines, increasing bentonite requirements and affecting winemaking efficiency. However, evaluating their spatial variability before harvest remains challengi...

CAF-1 in Replication and Repair: A Critical Genetic Mediator of Synthesis-Coupled Nucleosome Assembly

Current advances in understanding the molecular mechanisms by which human and yeast CAF-1 complexes are recruited to sites of DNA synthesis and how CAF-1 function is coordinated with other histone chaperones during replication and repair are summarized.

Improvement of functional and antioxidant properties of Sacha inchi protein through glycosylation with chitosan oligosaccharide

Comprehensive analysis of non-synonymous single-nucleotide polymorphism of human TSC1 and TSC2 genes: An in silico approach

Abstract Tuberous sclerosis complex (TSC) is an autosomal dominant disorder caused by mutations in the TSC1 and TSC2 genes and is characterized by benign hamartoma formation in multiple organs. The TSC1–TSC2 complex regulates mTORC1 signaling in response to cellular growth conditions. This study aims to predict the str...

Discovery and Characterization of a Novel Ligand-Binding Site in UFC1 Using Sulfa- and Sulfonate-Based Compounds

UFMylation is an important biological process where proteins are post-translationally modified via the covalent attachment of the ubiquitin-like modifier (UBL), ubiquitin-fold modifier-1 (UFM1). UFMylation is analogous to ubiquitination, occurring via the transfer of UFM1 across E1-, E2-, and E3-like enzymes, represe...