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2,039 papers
This work developed orthogonal methods to increase production or enhance stability of β-catenin, an important oncoprotein and target for degrader therapeutics, and used the dTAG system to evaluate the consequences for PROTAC activity.
These findings establish the Dnm2K562E/SC− mouse as a robust preclinical model, recapitulating key features of DNM2–Charcot–Marie–Tooth, and provide crucial insight into the biological and temporal constraints that must guide future therapeutic strategies for DNM2–Charcot–Marie–Tooth.
The findings indicate that multimodal phenotyping, coupled with explainable machine learning, offers a practical and biologically interpretable decision-support approach for chia genotype classification.
In vitro simulated digestion demonstrated its characteristic intestinal sustained-release behavior, which provides preliminary in vitro evidence that may favor enhanced intestinal absorption of α-linolenic acid (ALA); however, further cellular or animal trials are required to quantitatively validate its actual in vivo...
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How PilC/PilY1 can be retained on the fiber tip under enormous tensile loads generated during mechanical shear and T4P retraction is explained and how diverse T4P systems employ β-strand addition to license fiber assembly is demonstrated.
A structure dynamics-based design strategy is reported that transforms OB into a selective antibacterial agent through rational modification of the nitrophenyl moiety, and establishes a 'kinetic sensor' strategy for achieving species selectivity.
A hydrogel microsphere-based CHA method that integrates CHA signal amplification with the solid-phase carrier of hydrogel microspheres for the detection of miRNAs in blood samples with favorable application potential for the detection of miRNA biomarkers in complex biological samples with a simple, low-cost, enzyme-fre...
Suboptimal vitamin D status is highly prevalent among IBD patients in Misurata, Libya, with disease activity acting as the primary driver of vitamin D depletion regardless of patient gender, underscoring the critical need for continuous assessment and the implementation of effective supplementation strategies to improv...
Repeat proteins fold through pathways that are strongly shaped by local energetics, making them highly sensitive to mutations. The ankyrin repeat (AR) domain of IκBα is a cooperative folding unit in which the first four repeats (AR1–AR4) are stable, while the last two are destabilized. Despite this simple modular archi...
Temporal Wave Function Collapse Dynamics explores the theoretical underpinnings of the collapse of temporal wave functions – fundamental units of information within complex systems such as neural networks and protein folding – as a dynamic process. This paper posits that collapse isn't a discrete event but rather a con...
Using NMR, molecular dynamics simulations, and complementary kinase and binding assays, it is shown that Val234 acts as a crucial allosteric hub of PKG autoinhibition, explaining how distal mutations can unpredictably rewire kinase allostery and drive pathogenic vascular signaling.
Dynamic Symmetry Field Analysis (DSFA) is a novel technique for unraveling the intricate patterns within complex systems, specifically focusing on identifying and quantifying 'dynamic symmetry fields.' This research explores the potential of employing a new mathematical operator to analyze the evolution of these fields...
Proof of concept for watermarking AI-generated proteins while preserving biological function.
A new machine-learning framework aims to improve the success rate of computational protein design while moving away from results that reproduce sequences found in nature.
Scientists are using AlphaFold to strengthen a photosynthesis enzyme for resilient, heat-tolerant crops.
Explore how AlphaFold has accelerated science and fueled a global wave of biological discovery.
AlphaFold has revealed the structure of a key protein behind heart disease
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