Mechanisms supporting microbial survival under lethal selenite [Se(IV)] concentrations during bioremediation remain elusive. This study employed integrated multi-omics to analyze Lactiplantibacillus plantarum BSe (LPB) under extreme Se(IV) stress. LPB achieved 76.32% removal at 100 mM Se(IV), but this high efficiency c...
Weijun Xu, Xuesen Xia, Xiaoyin Wang et al.· BMC Microbiology· 0 citations
The potential molecular mechanisms by which Hedyotis diffusa alleviates lung injury from multiple perspectives are explored, providing experimental evidence and theoretical insights for further mechanistic studies and clinical drug development.
Aerial parts of native perennials Satureja montana and Teucrium montanum were spectrophotometrically compared on the levels of antioxidant potential, phenolics, soluble sugars and proteins, suggesting a greater potential for phenolic-associated bioactivity.
Biogenesis of the bacterial outer membrane is key to bacterial survival and antibiotic resistance. Central to this is the β-barrel assembly machine (Bam) complex and its associated chaperones, which are responsible for transport, folding and insertion of outer membrane proteins (OMPs). The Escherichia coli Bam complex...
Jack A. Bryant, Kara A Staunton, Hannah M. Doherty et al.· eLife· 0 citations
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We introduce a solid-phase synthesis platform for the rapid, modular, and scalable synthesis of the synthetic metallophore KO-NH2, which is readily recognized by bacterial siderophore transporters, but has optimized affinity for Ga3+ over Fe3+. Four synthetic protochelin (PC) analogues, KK-COOH, KO-NH2, KO-COOH, and OK...
Phuong Tran, Axia Marlin, Edith K. Amason et al.· Angewandte Chemie· 0 citations
In vitro biological activity of the generic drug Vapromin® is comparable to that of Evrysdi® (Roche, Basel, Switzerland) and further research should be conducted to confirm bioequivalence between the two products.
O. Strizhakova, A. Pershin, Yana Bahareva et al.· Biomedicines· 0 citations
Psychrophilic enzymes can have improved functionalities in low temperatures, which may be useful for improving the efficiency or sustainability of certain industrial processes. Little is known about the structure-function relationships of cold-adapted enzymes. In particular, the existence of pepsin-like proteases which...
Leslie Huynh· cIRcle (University of Britis...· 0 citations
Given the rapid spread of antibiotic resistance worldwide, it is imperative to develop new strategies against pathogenic bacteria. Here, we report a small-molecule inhibitor of bacterial heat shock protein 70 (Hsp70), called DnaK, a central component of the bacterial protein chaperone network. Screening of an in-house...
Tulsi Upadhyay, Reshma Kumari, Yogesh M. Gangarde et al.· ChemBioChem· 0 citations
Multidimensional machine-learning models predicted 48 h pediatric extubation success with strong internal discrimination and a low-severity phenotype and a high-severity phenotype were identified.
Binding of ligands to partially or fully unfolded proteins can play a key role in the mechanism of cellular and pharmacological chaperones, facilitating proper folding. However, it is challenging to quantify the binding affinity of ligands for unfolded states in a protein that is normally folded, as the methods standar...
Shubhadeep Patra, C. Garen, M. Woodside· bioRxiv· 0 citations
Together AAV-FST and VEGF therapy enhanced local muscle hypertrophy, increased capillary density, and improved the muscle-to-liver transgene expression profile compared with AAV-FST monotherapy, which supports further evaluation of angiogenic preconditioning as a strategy to improve muscle-directed gene therapy for mus...
A. Vakhrusheva, A. Nedorubov, V. Leshko et al.· bioRxiv· 0 citations
The analysis resolves an expanded BECR-fold landscape comprising canonical BECR and BECR-like superfamilies, refines the organization of canonical BECR proteins and identifies previously unrecognized families, and expands and clarify the BECR-fold landscape.
Kristi Pham, Gianlucca G. Nicastro, Audrey R. Long et al.· bioRxiv· 0 citations
A new machine-learning framework aims to improve the success rate of computational protein design while moving away from results that reproduce sequences found in nature.
