protein folding

A thermodynamic framework for mapping elastic recoil mechanism across the human proteome

A sequence-derived thermodynamic framework is introduced that maps proteins according to the relative contributions of backbone conformational entropy and solvent entropy to elastic recoil, suggesting that elastic function is far more widespread than currently recognized.

Autotaxin Inhibition Ameliorates HFpEF Phenotype By Reducing LPA-Mediated Systemic Inflammation and Cardiac Remodeling

In male mice with established two-hit HFpEF, autotaxin inhibition improved diastolic indices and reduced fibrosis, hypertrophy and cardiac myeloid accumulation and the autotaxin–LPA axis is nominated as a tractable therapeutic target.

Scalable Production of a De Novo SARS-CoV-2 Antiviral Miniprotein in Escherichia coli

Background/Objectives: The rapid emergence of SARS-CoV-2 variants that evade neutralizing antibodies underscores the need for new antiviral biologics that integrate precise molecular design with scalable, cost-effective manufacturing. Computationally designed miniproteins targeting the spike protein’s receptor-binding...

Topological Confinement Matrices and Asymptotically Rigid Hilbert Space Structures in Quantum Chemistry and Protein Folding (v1.0)

This preprint introduces the molecular and biochemical extension of The Bell TowerArchitecture. By taking the asymptotic limit (ε → 0) of the discrete lattice Z^3, we define acontinuous rigid field Φ(z) governed by Weierstrass infinite products and Mittag-Leffler expansions. This geometric framework replaces traditiona...

Title: Adaptive Symmetry in Fractal Networks

This paper introduces an innovative framework for analyzing and optimizing fractal networks, leveraging the concept of 'Symmetry Metric' to guide network design. We propose a novel method for quantifying network structure using a mathematical definition of self-similarity and employing this metric to optimize network p...

Title: Temporal Topology Optimization for Biological Systems

Temporal Topology Optimization (TTO) presents a novel approach to biological system optimization, moving beyond static parameterization to model the dynamic evolution of topological states. This paper introduces a system leveraging network theory and evolutionary dynamics to predict emergent behaviors within biological...

Chloramphenicol stress triggers oxidative adaptation in Acinetobacter baumannii ATCC19606 devoid of RND efflux pumps AdeAB or AdeIJ

The findings reveal efflux pump-specific and strain-specific adaptations to antibiotic stress, positioning CraA as a major determinant of chloramphenicol resistance, while RND transporters such as AdeABC and AdeIJK may also be associated with broader stress adaptation processes, including redox and metal homeostasis, i...

Title: Algorithmic Complexity of Parallel Simulations of Complex Systems

This paper investigates the algorithmic complexity of parallel simulations of complex systems, aiming to develop a novel algorithm that significantly reduces computational costs while maintaining accuracy. Complex systems, such as protein folding and climate modeling, demand substantial computational resources. Existin...

Title: Dynamic Evolutionary Algorithm for Protein Folding with Topology Preservation

Protein folding is a fundamental biological process, and achieving accurate and stable folding is critical for protein function. Current methods often struggle to preserve the intricate network of interactions within the protein structure, leading to misfolded proteins and disease. This paper introduces a novel Dynamic...

Analytical validation of a multiplexed peptide microarray for multi-antigen Epstein–Barr virus serological profiling across diverse clinical specimens

The platform as an analytically characterized, peptide-level EBV serology tool for translational research is supported, indicating that platform-level seropositivity reflects EBV exposure rather than an obvious MS-specific signal.

The Use of Fullerenol as a Seed Treatment to Maintain the Intensity of Physiological and Biochemical Processes of Wheat in Control and Low-Temperature Conditions

It is of utmost importance to investigate the effect of carbon-based nanostructures on plants in order to fully unlock their potential for enhancing productivity and stress tolerance. In this study, a comprehensive assessment of the effect of pre-sowing treatment of wheat seeds with fullerenol (PHF [C60(OH)24], 0.1 mg/...

Systematic In Silico Screening of Nigerian Medicinal Plant Phytoconstituents Against Six Breast Cancer-Associated Proteins