Background Antimicrobial resistance remains a top global health threat. While ATP-binding cassette (ABC) efflux pumps contribute to multidrug resistance in Gram-negative bacteria, their transcriptional regulation is far less understood than that of the RND and MFS families. Methods We used DNA pull-down followed by LC–...
Zhen-Yue Feng, Meng Wu, Chao-Huan Yang et al.· Frontiers in Microbiology· 0 citations
Biogenesis of the bacterial outer membrane is key to bacterial survival and antibiotic resistance. Central to this is the β-barrel assembly machine (Bam) complex and its associated chaperones, which are responsible for transport, folding and insertion of outer membrane proteins (OMPs). The Escherichia coli Bam complex...
Jack A. Bryant, Kara A Staunton, Hannah M Doherty et al.· 0 citations
Abstract Pattern recognition receptors such as FLAGELLIN SENSING 2 (FLS2) are central to plant immunity and attractive targets for engineering broader detection of bacterial phytopathogens for application in pest management (and diagnostics) in food crops and sustainable agriculture practices. However, evaluating numer...
The valorization of whey, the main byproduct of cheese manufacture, is hindered for small and medium-sized dairy enterprises (SMEs) by the high cost of conventional separation technologies such as membrane filtration and chromatography. In this work, complex coacervation between whey proteins and carboxymethylcellulo...
Sofía Baldor, Ana Briggiler, Ainara Gómez et al.· ACS Applied Polymer Material...· 0 citations
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Bromodomain and extra-terminal (BET) proteins are validated therapeutic targets for cancer, but clinical translation of pan-BET inhibitors is limited by dose-limiting toxicities from non-selective inhibition of BD1/BD2 domains. Herein, we report the first-ever domain-selective covalent inhibitor, named ipAE1, of BET BD...
Ji-Bo Kang, Xuan Wang, Hong Zhang et al.· Angewandte Chemie· 0 citations
The study of complex systems often faces challenges in characterizing their inherent dynamics and identifying emergent patterns. Traditional chaos theory metrics, while valuable, often fail to fully capture the nuanced interplay of non-linear interactions driving these patterns. This paper introduces the Dynamical Chao...
Jincheng Zhang· Zenodo (CERN European Organi...· 0 citations
The study of complex systems often faces challenges in characterizing their inherent dynamics and identifying emergent patterns. Traditional chaos theory metrics, while valuable, often fail to fully capture the nuanced interplay of non-linear interactions driving these patterns. This paper introduces the Dynamical Chao...
Jincheng Zhang· Zenodo (CERN European Organi...· 0 citations
Overall, plant-derived peptides show directionally consistent bioactivity in Caco-2 models, but the evidence rarely identifies the responsible molecular species or confirms physiological attainability, and future work should prioritise metabolic characterisation, exposure-justified concentrations, and multi-omics appro...
Simone Perna, M. Di Nunzio· International Journal of Mol...· 0 citations
Edaphic antibiotic resistance genes (ARGs) have garnered worldwide concern, yet mechanisms by which specific microbial taxa drive ARG variation under anthropogenic stress remain unclear. Here we show how opportunistic and sensitive taxa contribute to ARG propagation in soil microcosms exposed to conventional (polyethyl...
Ying Li, Jiaxin Shi, Yu Wang et al.· Communications Earth & Envir...· 0 citations
This paper investigates the statistical topology of complex structures, focusing on the identification of underlying patterns and prediction of emergent behavior within datasets exhibiting inherent statistical properties. We propose a novel method, the "Resonance Field" concept, to quantify these properties and establi...
Jincheng Zhang· Zenodo (CERN European Organi...· 0 citations
ABSTRACT Bromodomain and extra‐terminal (BET) proteins are validated therapeutic targets for cancer, but clinical translation of pan‐BET inhibitors is limited by dose‐limiting toxicities from non‐selective inhibition of BD1/BD2 domains. Herein, we report the first‐ever domain‐selective covalent inhibitor, named i p AE1...
Jibo Kang, Xuan Wang, Hong Zhang et al.· Angewandte Chemie· 0 citations
Biogenesis of the bacterial outer membrane is key to bacterial survival and antibiotic resistance. Central to this is the β-barrel assembly machine (Bam) complex and its associated chaperones, which are responsible for transport, folding and insertion of outer membrane proteins (OMPs). The Escherichia coli Bam complex...
Jack A. Bryant, Kara A Staunton, Hannah M Doherty et al.· 0 citations
A new machine-learning framework aims to improve the success rate of computational protein design while moving away from results that reproduce sequences found in nature.
