Rosmarinic acid (RA) significantly alleviates DSS-induced colitis by repairing the damaged colonic mucus barrier and reversing gut microbiota dysbiosis. However, it remains unclear whether the gut microbiota is required for this protective effect. To address this, pseudo-germ-free mouse models and fecal microbiota tran...
This study establishes a robust chassis for sustainable DPA production and provides a generalizable framework for engineering other valuable biochemicals.
Qing Yang, Tao-Shun Zhou, Bo Zhang et al.· Biotechnology and Bioenginee...· 0 citations
Older patients account for a growing share of emergency department (ED) visits with heterogeneous risk that conventional triage does not capture. The Clinical Frailty Scale (CFS) reflects baseline reserve and the C-reactive protein-to-albumin ratio (CAR) reflects acute inflammatory–nutritional stress. Whether com...
S. Bae, Dong-Hoon Lee, H. Chung et al.· BMC Geriatrics· 0 citations
Glucagon-like peptide-1 (GLP-1) is a key incretin hormone involved in glucose regulation and metabolic health. This study reports, for the first time, the GLP-1 enhancing potential of a standardized
Coleus forskohlii
extract (Leanskolin™, ≥ 10% forskolin) using differentiated Caco-2 cells. MTT assay was performed...
H. Sudeep, Thammatadhahalli Parameshwarappa Prasanna Kumara, H. Lingaraju et al.· BMC Complementary Medicine a...· 0 citations
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In the current study, by integrating the analyses of lipidomics and proteomics, the compositional differences between colostrum and mature milk of Holstein cows were systematically investigated. We have identified a total of 1863 lipid metabolites and 1690 proteins. A small portion of them were highly differentiated be...
Hao Wu, Peng Wang, Peng-Yun Ji et al.· Foods· 0 citations
An integrated WRRA Core 1.0 study that derives the minimum functional architecture required for directional intracellular walking and maps it to a synthesis-addressable hybrid protein candidate. The report presents H2-b2f820d18e, consisting of the inherited human kinesin-1 KIF5B 1–353 motor core and a designed 32-amino...
Wonsik Choi· Zenodo (CERN European Organi...· 0 citations
Lung cancer with multiorgan metastasis remains the leading cause of cancer death. Current CT imaging and biopsy are suboptimal for detecting early tumors or subclinical metastases. We address this gap using LUAD with LKB1/STK11 inactivation, which alters collagen via focal adhesion kinase activation. Collagen I overexp...
Dongjun Li, Oluwabukola Bamishaye, Sandi Li et al.· Science Advances· 0 citations
An integrated WRRA Core 1.0 study that derives the minimum functional architecture required for directional intracellular walking and maps it to a synthesis-addressable hybrid protein candidate. The report presents H2-b2f820d18e, consisting of the inherited human kinesin-1 KIF5B 1–353 motor core and a designed 32-amino...
Wonsik Choi· Zenodo (CERN European Organi...· 0 citations
Dextran sodium sulfate (DSS) is widely used in vivo to induce epithelial injury; however, the epithelial-specific responses to DSS and mechanisms associated with barrier restoration remain incompletely understood. Here, we establish an in vitro DSS-induced epithelial damage model using differentiated Caco-2 cell monola...
Srijal Kunwar, S. Naser· International Journal of Mol...· 0 citations
More frequent short-term episodes of extreme high temperatures caused by global warming seriously threaten plant growth and development around the world. Although heat stress can occur throughout the plant life cycle, exposure during the seedling stage severely impacts subsequent plant growth and productivity. In this...
Lin Chen, Xiao-Chun Ge· Frontiers in Plant Science· 0 citations
Caenorhabditis elegans has served as a model for the unfolded protein response of the endoplasmic reticulum (UPR-ER) and, separately, the oxidative stress response coordinated by SKN-1/Nrf. The oxidative protein folding in the ER generates reactive oxygen species, which is one reason why these systems are frequently st...
A new machine-learning framework aims to improve the success rate of computational protein design while moving away from results that reproduce sequences found in nature.
