This repository contains the code and analysis workflows associated with the publication "Serum Proteome Profiling Reveals a Candidate Biomarker Signature for Paediatric Chronic Nonbacterial Osteomyelitis (CNO)/Chronic Recurrent Multifocal Osteomyelitis (CRMO)” by Eve Roberts, Euan McDonnell, Phillip Brownridge, James...
Euan McDonnell· Zenodo (CERN European Organi...· 0 citations
Traumatic brain injury (TBI) has long-term consequences that include chronic traumatic encephalopathy (CTE) and an elevated risk for Alzheimer's disease (AD). These dementias ultimately manifest as tauopathies but may begin with acute neuronal dysfunction including post-traumatic seizures. Provocative evidence suggests...
Laszlo F. Locskai, Shayleen Ghassemi, Samantha A. W. Tan et al.· Experimental Neurology· 0 citations
This manuscript proposes a theoretical application of the General Epistemic Dispersion Theory (GEDT) to the domain of molecular biology, utilizing adult human hemoglobin (HbA) as a model study. The work formalizes protein folding as a configurational reconstruction problem, investigating how informational load is parti...
Massimo Comitato· Zenodo (CERN European Organi...· 0 citations
Together, these results establish a scalable strategy for accessing previously unexplored Rubisco sequence space, providing a broadly accessible path toward generating de novo Rubiscos that have activity and specificity parameters needed to address longstanding limitations in biological carbon fixation.
Alexander J. Kehl, Simon K. S. Chu, J. H. Pereira et al.· bioRxiv· 0 citations
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Motivation. Variant effect predictions are most interpretable when read against structure, and this is already available for human proteins: the AlphaFold database displays AlphaMissense pathogenicity as a residue-level heat map on the predicted fold, and proteome-wide language model predictions have been published wit...
Rashid Karim· Zenodo (CERN European Organi...· 0 citations
A series of fluorine-containing pyrazole benzamide derivatives were designed and synthesized. Compound Z1 exhibited significantly higher activity against P. xylostella (LC50 = 0.203 mg/L) than that of ethiprole (LC50 = 2.88 mg/L). Compounds Z1, Z8, and Z20 showed over 13-fold higher activity against S. frugiperda (LC...
Wei Sun, Xin-Yi Zhang, An-Jing Liao et al.· Journal of Agricultural and...· 0 citations
OBJECTIVES
The activity-regulated cytoskeleton-associated protein (Arc) is essential for synaptic plasticity and memory formation. Arc binds RNA and self-assembles into capsid-like structures reminiscent of retroviral Gag proteins, but the molecular basis of this interaction remains poorly defined. This study sought to...
Aya Al Othman, T. Lupanova, Dmitry Bagrov et al.· NeuroReport· 0 citations
Acyl-homoserine lactone (AHL) quorum sensing enables many species of proteobacteria to coordinate collective behaviors. In such systems, a synthase produces an AHL signal, which is sensed by a LuxR-family receptor. Despite extensive genomic annotation of LuxR homologs, preferred AHLs for most receptors remain unknown,...
Davi Nakajima An, A. Schaefer, Szu-Min Chang et al.· bioRxiv· 0 citations
Acute pancreatitis (AP), a prevalent inflammatory condition, can result in systemic complications, including myocardial injury. Nevertheless, the dynamic transcriptomic alterations and key molecular mechanisms underlying pancreatic-associated cardiac complications during AP progression are still not fully elucidated. M...
Xi-Jing Zhuang, Xiao Han, Chang Xu et al.· Biochemistry and Biophysics...· 0 citations
This dataset contains processed transcriptomic and proteomic data generated from inguinal white adipose tissue collected from control mice, obesity-associated PCOS model mice, and PCOS mice treated with high-dose Atractylodis Rhizoma-derived exosome-like nanovesicles (AR-ELNs). These data support the multi-omics analys...
Cognitive impairment was highly prevalent in patients undergoing coronary angiography and was consistently associated with the presence and extent of coronary and systemic atherosclerotic disease.
M. A. Nashtar, Haris Sehovic, O. Azizy et al.· European Journal of Medical...· 0 citations
Aging is a major contributor to the decline in egg quality, with uterine inflammaging playing a key role in this process. Implementing anti-aging strategies to prevent uterine inflammaging and sustain optimal eggshell quality is imperative. This study aimed to characterize age-related changes in the eggshells and ute...
Dan Shao, Yuan Qu, Liang Qu et al.· Frontiers in Immunology· 0 citations
A new machine-learning framework aims to improve the success rate of computational protein design while moving away from results that reproduce sequences found in nature.
