Sep 2026· Zenodo (CERN European Organization for Nuclear Research)
Microtubule and mitosis dynamics
Abstract
An integrated WRRA Core 1.0 study that derives the minimum functional architecture required for directional intracellular walking and maps it to a synthesis-addressable hybrid protein candidate. The report presents H2-b2f820d18e, consisting of the inherited human kinesin-1 KIF5B 1–353 motor core and a designed 32-amino-acid WRRA gate, together with its 385-amino-acid protein sequence and 1,158-nucleotide candidate coding DNA. It explains the two-contact state-transition cycle, ATP-driven directional movement, microtubule polarity, present-state gating, design provenance, computational validation strategy, experimental controls, risks, and the boundary between formal proof, computational prediction, and experimental evidence. H2 remains a PREDICTED_SEQUENCE_ONLY hybrid motor candidate; its folding, dimerization, ATPase activity, processive walking, and intracellular cargo transport remain open for validation.
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