Background/Objectives: This study investigated the potential of nanostructured lipid carriers (NLCs) to improve the in vitro skin delivery and retention of bioactive compounds derived from Bombyx mori silk cocoon. Furthermore, an NLC-based facial serum was developed and clinically evaluated for its efficacy and safety....
C-reactive protein (CRP) is an inflammatory biomarker with prognostic value in heart failure, but its role in HeartMate 3 (HM3) left ventricular assist device recipients is unclear. We retrospectively analyzed 188 adult HM3 recipients (2016-2025), stratified by preoperative CRP into low-CRP (≤10 mg/L, n = 65) and high-...
J. Eisenberger, Eyal Nachum, Shmuel Somer et al.· ASAIO journal (1992)· 0 citations
An approach to analyze long-timescale kinetics of molecular dynamics simulations - meta-stable states and transition timescales - by a tensor-based approximation of the infinitesimal generator is presented, and the number of reaction coordinates can be gradually increased without having to solve the variational problem...
Minakshi Verma, Peter Benner, F. Nüske· 0 citations
Collectively, the recombinant PDI protein exhibits good biocompatibility and pro-adhesive activity, demonstrating its potential as a candidate raw material for skin-repair cosmetics.
Unknown authors· Bioengineering· 0 citations
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These findings uncouple NAP1 abundance from the availability of a canonical nucleosomal substrate and suggest evolutionary repurposing toward non-nucleosomal roles in chromosome-territory organization, helping define the minimal functional core of this conserved chaperone family.
K. Yan, A. Kwok, Shao-Ping Wen et al.· International Journal of Mol...· 0 citations
The molecular attributes acquired at each stage of PF production and the epitope changes originating during processing are explored, the current assessment scheme is reevaluated, and considerations for a premarket safety framework reflecting realistic processing and consumption conditions are outlined.
Multimodal diagnostic strategies and risk stratification are essential for improving early lung cancer detection, clinical outcomes, and personalized interventions. To develop a predictive model for lung cancer incidence by integrating plasma proteomics, genetic factors, and demographic data. We analyzed data from the...
Fan Yang, Xi-Rui Qiu, Wei Wang et al.· International Journal of Can...· 0 citations
It is found that, beyond its native Class I-type ETS (Adx/AdR), CYP11A1 can also function with diverse Class II-type ETSs (CPRs) across species, and the F75S mutation improves overall catalytic efficiency by strengthening interfacial interactions between SsCYP11A1 and AoCPR and stabilizing a catalytically favorable con...
It is shown how antigen‐detected NMR can support peptide engineering and structure‐guided protein binder selection against minimal epitopes against minimal epitopes.
Jun-Yu Liu, Wan-Lin Chen, B. Cristofori-Armstrong et al.· Advancement of science· 0 citations
A CMOS‐compatible p‐bit is reported that harnesses intrinsic random telegraph noise (RTN) in a fully depleted silicon‐on‐insulator field‐effect transistor to produce stochastic binary outputs with direct gate‐voltage control, providing a physically grounded pathway toward CMOS‐based probabilistic processors.
Unknown authors· Advancement of science· 0 citations
The identified and characterized an H⁺-PPase gene (SaH-PPase) from the cosmopolitan bloom-forming dinoflagellate Scrippsiella acuminata and the findings provide novel molecular insights into the survival mechanisms of resting cysts and lay a foundation for understanding the physiological adaptations of dinoflagellates...
Hanying Zou, Fengting Li, Jia-Qi Lu et al.· Harmful Algae· 0 citations
A new machine-learning framework aims to improve the success rate of computational protein design while moving away from results that reproduce sequences found in nature.
