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Vesicle-associated membrane protein-associated protein B (VAPB) is an endoplasmic reticulum protein implicated in amyotrophic lateral sclerosis (ALS) through its P56S mutation. Although pathological function loss and condensate formation of the VAPB P56S mutant are crucial for disease progression, the underlying mole...
A comprehensive RNA-sequencing analysis of postmortem nucleus accumbens tissue from individuals with OUD and matched controls provides an integrated view of candidate genetic and transcriptomic alterations in OUD and identifies lncRNA-centered regulatory networks and candidate variant-bearing genes as hypothesis-genera...
Overview This paper addresses the P versus NP problem by proposing a fundamental epistemological and geometric rupture. Rather than treating the "combinatorial explosion" characteristic of NP problems as an intrinsic physical or mathematical barrier, this work demonstrates that it is an artifact of measuring a multi-di...
Immune-checkpoint inhibitors targeting PD-1 and CTLA-4 have transformed cancer therapy, yet most patients still fail to respond, and the reasons remain incompletely understood. To dissect this heterogeneity and support translational development, we built a preclinical quantitative systems pharmacology model of α-PD-1...
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Background: Euryale ferox Salisb. seed (Euryales Semen) is a traditional Chinese medicine whose therapeutic application is modulated by wheat bran stir-frying, a process that enhances its effects on tonifying the spleen and kidney. The molecular mechanisms and alterations in bioactive components underlying this process...
Source data underlying the figures and supplementary data of this manuscript.- figshare_Figure_data.xlsx: Numerical source data for Figures 1, 3, 4, 5, 6, and 7 (19 sheets, one per panel).- figshare_Data Set S1.xlsx: Differential protein expression results (log2 fold change, p-value) for three pairwise comparisons amon...
Grasspea (Lathyrus sativus L.) is a versatile, climate-resilient legume valued for its nutritional richness and low input requirements. However, the presence of the neurotoxin β-N-oxalyl-L-α, β-diaminopropionic acid (β-ODAP) has limited its popularity. The present study aimed to identify promising low-ODAP grasspea gen...
Bronchiectasis is increasingly recognised as a chronic airway disease, but is often diagnosed only after irreversible structural abnormalities have developed. To characterize plasma molecular patterns preceding the first recorded bronchiectasis diagnosis, we analysed baseline plasma proteomics in the UK Biobank Pharma...
These models could support triage and prioritization of patients already under evaluation for suspected MM, particularly where access to specialized testing is delayed; use in lower-prevalence, first-contact settings would require recalibration and dedicated validation.
A condition-dependent condensate state for CC1NTD is defined and a novel mechanism for the formation and maintenance of stress-associated cellulose synthase compartments driven by LLPS of the disordered regions of CSC and accessory proteins is proposed.
SLFN5 is a DNA- and RNA-binding protein with endonuclease activity on specific RNA substrates, which determines the role of SLFN5 as a tumor suppressor.
Tideglusib is established as a mechanistic chemical probe for NatA, NatA is revealed as a previously unrecognized molecular target for a promiscuous clinical-stage investigational compound, and a conceptual framework for exploiting catalysis-dependent adduct formation as a new strategy for acetyltransferase inhibitor d...
Proof of concept for watermarking AI-generated proteins while preserving biological function.
A new machine-learning framework aims to improve the success rate of computational protein design while moving away from results that reproduce sequences found in nature.
Scientists are using AlphaFold to strengthen a photosynthesis enzyme for resilient, heat-tolerant crops.
Explore how AlphaFold has accelerated science and fueled a global wave of biological discovery.
AlphaFold has revealed the structure of a key protein behind heart disease
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