Knee osteoarthritis (OA) is a disabling whole-joint disease involving synovial inflammation and myeloid-cell activation. A-to-I RNA editing can regulate endogenous dsRNA sensing and protein recoding, but its dynamics across synovial monocyte-macrophage cell states remain unclear. We analyzed 12 RNA-seq libraries from s...
Yingming Chu, Boyang Yi, Xinyue Cao et al.· Human Genomics· 0 citations
The applicable boundaries and complementary relationship between CRISPRoff and CRISPRon are clarified and a theoretical direction for tool selection and collaborative strategies is provided, such as in vivo collaborative application and delivery efficiency.
Yi-Zhi Wang· Explore Medical Science and...· 0 citations
India regulates two of the twenty-first century's most ethically fraught technologies, consumer and clinical neurotechnology, and human germline gene editing, almost entirely through non-binding administrative guidance rather than enforceable statute. This paper examines that pattern through two case studies: the treat...
Sachin Chauhan· Zenodo (CERN European Organi...· 0 citations
NEW AUDIO INTERVIEW - Camilo Fernández Bravo, MD/PhD/FACC, Editor in Chief, on the Future of Clinical and Translational Cardiology** --- **HOST:** Welcome to our New Audio Interview series. Today we have a true leader in modern cardiology. Dr. Camilo Fernández Bravo, MD, PhD, FACC, Editor in Chief of the Journal of Cli...
Camilo Fernández Bravo· Zenodo (CERN European Organi...· 0 citations
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Artificial intelligence (AI) has emerged as a transformative force in plant genetics and genetic engineering, addressing long-standing challenges in trait complexity, breeding cycle duration, and genome-editing precision. The convergence of machine learning, deep learning, and multi-omics integration enables the decodi...
Subhadwip Ghorai, Suvojit Bose, Ankur Mukhopadhyay et al.· 0 citations
Artificial Intelligence (AI) has revolutionized plant systems biology via the possible combination of multi-omics data, higher-order modeling, and autonomous hypothesis construction. Through deep learning, machine learning, and hybrid models, AI interprets complex genotype–phenotype connections and aids predictive mode...
A validated CRISPR-Cas9 strategy for high extracellular β-galactosidase secretion in the clinically established S. boulardii CNCM I-745 is demonstrated, providing a foundation for future studies where the potential of the developed strains is evaluated in clinically relevant settings.
J. Carvalho, David Sáez Moreno, Carlos E. Costa et al.· Microbiology Research· 0 citations
Key CRISPR-derived tools are introduced, including base editors, prime editors, and programmable transcriptional and epigenetic regulators, and remaining challenges to stimulate future exploration of the full potential of CRISPR toolkits are outlined.
Zhen-Xiang Li, Xiang-Yu Xiong, Ren-Qi Cao et al.· Plant Physiology· 0 citations
Data support initiation of a first-in-human phase I trial of CRISPR_SCD001 for sickle patients presenting with severe pathology, and generates a clinical-grade, cryopreserved CD34+ cell product that corrects the sickle mutation, restores anti-sickling hemoglobins, and meets pre-clinical safety criteria.
M. DeWitt, Beatriz Campo-Fernández, Sohini Roy et al.· Molecular Therapy· 0 citations
Astrocytes are intriguing therapeutic targets due to their crucial role in initiating and promoting demyelination in the central nervous system. By efficient on-target editing, we can permanently disrupt detrimental genes and restore normal physiological processes. Here, we have optimized an AAV platform to deliver the...
Anne E. J. Hillen, I. Capuano, Barbara Gega et al.· Molecular Therapy· 0 citations
Cancer‐testis antigens (CTAs) represent a unique class of tumor‐associated antigens (TAAs) with highly restricted expression in immune‐privileged tissues and widespread aberrant activation in various malignancies. Their potent immunogenicity and tumor specificity make CTAs promising targets for cancer immunotherapy. Th...
Ran-Ran Shi, Ling Ran, Tian-Tian Song et al.· Journal of Immunological Res...· 0 citations
It is demonstrated that DOR is the first member of the tomato SPPL gene family known to be associated with root development and adventitious organogenesis and Overexpression of this gene in the mutant has enabled the regeneration of plants with a wild-type phenotype.
M. Jáquez-Gutiérrez, S. Bretones, Constanza Martin-Vásquez et al.· Plant Cell Reports· 0 citations
Exploring how generative AI could make machine vision more accessible to businesses. The post GenEye in a Box: Making Machine Vision Something You Can Just Ask For appeared first on GPT-Lab.
