Preprint — not yet peer reviewed. This pilot computational study evaluates a TCGA gene-expression cancer classifier across six cancer types: BRCA, COAD, READ, LUAD, LUSC, and OV. The analysis focuses on patient-grouped cross-validation, training-only preprocessing, class-specific performance, tissue-source-site confoun...
Hitesh Sharma· Zenodo (CERN European Organi...· 0 citations
How advances in large DNA assembly, synthetic biology, and genome-wide validation are making chromosome-scale genome engineering an increasingly tractable experimental framework for understanding, building, and repairing genomes is discussed, while outlining the analytical requirements and current technical barriers th...
Miriam Saponaro, Pierre Murat, Francesca Agostini et al.· Trends in Genetics· 0 citations
A complete, gap-free genome of Medicago lupulina, a tough, high-protein forage legume, and a gene-editing tool for this species, which was used to alter its leaf shape, provide key resources for improving alfalfa and breeding better forage crops for high-altitude environments.
Qing Yuan, Cheng Li, Guang-Yan Wang et al.· Journal of Integrative Plant...· 0 citations
Overall, CRISPR-based technologies show considerable potential to support precision oncology in prostate cancer by enabling molecularly informed therapeutic strategies and addressing treatment resistance, although challenges related to delivery, off-target effects, tumor heterogeneity, immunogenicity, and clinical tran...
Vaibhavkumar Patel, Pratichi Singh, S. Dutta et al.· Critical reviews in oncology...· 0 citations
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This study establishes the feasibility of dCasRx-mediated programmable RNA base editing in plant cells and lays a foundation for further optimization of editing efficiency and stable in planta editing performance.
Xue-Ming Ruan, Zi-Yan Zhang, Xiang-Yu Xiong et al.· Biochemical and Biophysical...· 0 citations
The adaption of the continuous directed evolution (CDE) along with base editor (BE) gene editing strategy to discover TEM-1 mutants is reported here and highlights the application of gene editing methods to provide insight into the molecular basis of antibiotic resistance.
Hong Wang, Jia-Mei Wang, Ding-Jue Zhang et al.· Biotechnology Letters· 0 citations
Aims: This study develops a dynamic explanation for the gap between task-level artificial intelligence productivity and durable enterprise value. It introduces verification debt, the accumulated stock of unverified assumptions, weak review, concealed dependencies, deferred validation, and capability loss.
Study Design:...
Kwan-Hong Tan· Journal of global economics,...· 2 citations
CRISPR-Cas12a represents an efficient tool for genome editing in addition to the extensively investigated CRISPR-Cas9. However, development of efficient nonviral delivery system for CRISPR-Cas12a remains challenging. Here, we demonstrate a DNA nanoclew (NC)-based carrier for delivery of Cas12a/CRISPR RNA (crRNA) ribonu...
Xingwu Zhou, Jinqiang Wang, Quanyin Hu et al.· UNC Libraries· 0 citations
NEW AUDIO INTERVIEW - Camilo Fernández Bravo, MD/PhD/FACC, Editor in Chief, on the Future of Clinical and Translational Cardiology** --- **HOST:** Welcome to our New Audio Interview series. Today we have a true leader in modern cardiology. Dr. Camilo Fernández Bravo, MD, PhD, FACC, Editor in Chief of the Journal of Cli...
Camilo Fernández Bravo· Zenodo (CERN European Organi...· 0 citations
India regulates two of the twenty-first century's most ethically fraught technologies, consumer and clinical neurotechnology, and human germline gene editing, almost entirely through non-binding administrative guidance rather than enforceable statute. This paper examines that pattern through two case studies: the treat...
Sachin Chauhan· Zenodo (CERN European Organi...· 0 citations
# M-SCAN RNA-to-pFBA Tutorial M-SCAN builds Human-GEM reaction-capacity constraints from RNA expression, optional deleterious mutation attenuation, predicted kcat values, and medium constraints, then runs pFBA. The bundled three-sample CCLE example reproduces the Figure 2 mini-reference outputs and is also a template f...
Songwon Lim, Jae Woo Baek, Y David Seo et al.· WorkflowHub· 0 citations
Sense‒antisense overlapping gene pairs are widespread in plant genomes and constitute an important layer of gene regulation. However, only a few natural antisense transcripts (NATs) have been functionally characterized, primarily as regulators of their sense counterparts via small RNAs or long noncoding RNAs. Here, we...
Shu-Min Li, Fu-Jie Chang, Xiao-Chun Wang et al.· Rice· 0 citations
Exploring how generative AI could make machine vision more accessible to businesses. The post GenEye in a Box: Making Machine Vision Something You Can Just Ask For appeared first on GPT-Lab.
