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gene editing

1,407 papers

#gene editing Open access Sep 2026

Emerging Technologies in STEM: Systems Architecture, Cross-Disciplinary Migration, and Technology Readiness Dynamics

This comprehensive foundational module analyzes the systems architecture and developmental mechanics of emerging technologies across the modern STEM curriculum. Developed by Prep4Uni.Online, this resource serves as an analytical bridge connecting laboratory-stage scientific discovery to scalable industrial engineering...

Prep4Uni.Online · 0 citations
#gene editing Open access Sep 2026

Mitoxyperilysis-ARDS: analysis code, six-layer gene signature, and frozen statistical outputs for "Mitoxyperilysis-consistent L4 de-protection in human sepsis-associated ARDS blood: a compartment- and etiology-bounded transcriptomic boundary map" (archive v6; v2.34)

This archive supports the manuscript "Mitoxyperilysis-consistent L4 de-protection in human sepsis-associated ARDS blood: a compartment- and etiology-bounded transcriptomic boundary map" (submission target: Critical Care, BMC; manuscript version v2.34, September 2026). Contents: (1) complete analysis code (R 4.6.1 / Pyt...

linhuangwei, Yuanshui Liu · 0 citations
#gene editing Open access Sep 2026

Optimizing CRISPR–Cas9-mediated TCR knockout in primary mouse CD8+, CD4+, and regulatory T cells

CRISPR–Cas9 genome editing has transformed biomedical research by enabling precise and efficient genetic modification. Among its applications, gene knockout using ribonucleoprotein (RNP) complexes provides a non-viral strategy for introducing loss-of-function mutations. Here, we present an optimized CRISPR–Cas9 RNP-bas...

Andrea Šarac, Klemen Kunej, Kristina Manzoni et al. · 0 citations
#gene editing Open access Sep 2026

Click-Chemistry Functionalized Lipid Nanoparticles for In Vitro and In Vivo Transfection of Primary Human CD4+ T Cells.

CD4+ T cells orchestrate adaptive immunity and strategies that enable their genetic reprogramming hold promise for treating cancer, immune dysregulation and infectious diseases such as HIV. However, current T cell engineering approaches rely heavily on ex vivo manipulation, which is labor-intensive, costly, and can alt...

Maaike De Cock, Elianne Burg, Sarah Gerlo et al. · 0 citations
#gene editing Open access Sep 2026

CRISPR-Based Epigenome Editing for Precision Medicine: Molecular Mechanisms, Therapeutic Applications, Delivery Challenges, and Future Clinical Translation

Abstract Cancer, neurologic diseases, cardiovascular disease, metabolic disorders, immune disorders, and some inherited diseases are examples of epigenetic diseases. Traditional epigenetic drugs are non-specific and may be toxic at higher concentrations, may be unstable in transcription, and may have off-target effects...

Nicky Kumar Jaiswal, Adars Bharaddwaj, ANSHKUMAR BHUVA · 0 citations
#gene editing Open access Sep 2026

A Pilot Reproducibility and Robustness Assessment of a TCGA Gene-Expression Cancer Classifier

Preprint — not yet peer reviewed. This pilot computational study evaluates a TCGA gene-expression cancer classifier across six cancer types: BRCA, COAD, READ, LUAD, LUSC, and OV. The analysis focuses on patient-grouped cross-validation, training-only preprocessing, class-specific performance, tissue-source-site confoun...

Hitesh Sharma · 0 citations
#gene editing Open access Sep 2026

Hypertrophic Wasp Stem Cell Bio-Hybrid Muscle Actuator Powered and Cryogenically Cooled by Ethanol Solution

A novel theoretical concept in bio-hybrid robotics and tissue engineering: a macroscopic biological muscle actuator engineered from the stem cells of the Oriental Hornet (Vespa orientalis). The system utilizes CRISPR-Cas9 genome editing to multiply the Alcohol Dehydrogenase (NADP+) gene for absolute alcohol immunity, c...

Lucian-Razvan Popovici · 0 citations
#gene editing Open access Sep 2026

Hypertrophic Wasp Stem Cell Bio-Hybrid Muscle Actuator Powered and Cryogenically Cooled by Ethanol Solution

A novel theoretical concept in bio-hybrid robotics and tissue engineering: a macroscopic biological muscle actuator engineered from the stem cells of the Oriental Hornet (Vespa orientalis). The system utilizes CRISPR-Cas9 genome editing to multiply the Alcohol Dehydrogenase (NADP+) gene for absolute alcohol immunity, c...

Lucian-Razvan Popovici · 0 citations
#gene editing Open access Sep 2026

Emerging Technologies in STEM: Systems Architecture, Cross-Disciplinary Migration, and Technology Readiness Dynamics

This comprehensive foundational module analyzes the systems architecture and developmental mechanics of emerging technologies across the modern STEM curriculum. Developed by Prep4Uni.Online, this resource serves as an analytical bridge connecting laboratory-stage scientific discovery to scalable industrial engineering...

Prep4Uni.Online · 0 citations
#gene editing Open access Sep 2026

Hypertrophic Wasp Stem Cell Bio-Hybrid Muscle Actuator Powered and Cryogenically Cooled by Ethanol Solution

A novel theoretical concept in bio-hybrid robotics and tissue engineering: a macroscopic biological muscle actuator engineered from the stem cells of the Oriental Hornet (Vespa orientalis). The system utilizes CRISPR-Cas9 genome editing to multiply the Alcohol Dehydrogenase (NADP+) gene for absolute alcohol immunity, c...

Lucian-Razvan Popovici · 0 citations
#gene editing Open access Sep 2026

Does adjustment for tumor proliferation shift prognostic gene expression associations in a way that is predicted by each gene's correlation with proliferation? A confirmatory analysis across cancer types in The Cancer Genome Atlas

1. What is already done, and what this document covers I state this first, because the value of a preregistration written after related work depends on being exact about what was already seen. Three analyses are already complete and are exploratory. None of them was preregistered, and none of them is covered by this do...

Soon Woo Nam · 0 citations
#gene editing Open access Sep 2026

CRISPR-Based Epigenome Editing for Precision Medicine: Molecular Mechanisms, Therapeutic Applications, Delivery Challenges, and Future Clinical Translation

Abstract Cancer, neurologic diseases, cardiovascular disease, metabolic disorders, immune disorders, and some inherited diseases are examples of epigenetic diseases. Traditional epigenetic drugs are non-specific and may be toxic at higher concentrations, may be unstable in transcription, and may have off-target effects...

Nicky Kumar Jaiswal, Adars Bharaddwaj, ANSHKUMAR BHUVA · 0 citations

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