Advances in pangenomics, multi-omic integration, and gene-editing technologies are helping to overcome limitations in conventional GWASs by improving candidate-gene identification and functional validation, moving cereal genomics from statistical association toward biologically validated targets for developing more res...
Helmy M. Youssef, Radwa Y. Helmi, A. Börner et al.· Biology· 0 citations
Aim This study proposes the implementation of clustered regularly interspaced short palindromic repeats (CRISPR)–CRISPR-associated protein 9 (Cas9) technology for gene therapy targeting genetic mutations of P53 gene in human lymphocytes affected by chronic lymphocytic leukemia, (CLL), offering new opportunities for eff...
Aurelian Udriştioiu· Open Science Framework· 0 citations
A key safety concern for gene-edited (GE) crops is whether unintended molecular changes associated with gene editing pose risks to non-target organisms (NTO). Here, we combined proteomic and metabolomic profiling with insect bioassays to assess the effects of two GE wheat lines (mildew resistance Locus O (MLO)- and Tri...
Xiu-Ping Chen, Yuan-Yuan Wang, Hui-Lin Yu et al.· Ecotoxicology and Environmen...· 0 citations
This study describes the development and application of a wheat-compatible prime-editing system to introduce the Lr67-associated TaSTP13(G144R) resistance allele into the A, B, and D TaSTP13 homoeologs of hexaploid wheat. Edited lines were generated and characterized for editing efficiency, followed by evaluation of le...
Rafael E. Venado, Joshua Waites, Easter D. Syombua et al.· Figshare· 0 citations
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The genus Sorbus sensu lato (Maleae, Rosaceae) represents one of the most taxonomically complex groups in Rosaceae due to extensive hybridization, polyploidization, and morphological convergence. Although East Asia represents a major center of diversity for Sorbus s.l., the organellar genomes of East Asian simple-leave...
Xiong Li, Yu Feng, Chengwu Liu et al.· BMC Plant Biology· 0 citations
Cancer immunotherapy is a transformative technology allowing for the elimination of malignant cells through immune system stimulation; however, the large-scale clinical application of adoptive cellular therapy technologies is limited due to difficulties in
ex vivo
immune cell engineering, high costs, and complicate...
Hari Krishnareddy Rachamala, Sandeep Atla, R. S. Angom· Frontiers in Pharmacology· 0 citations
This study describes the development and application of a wheat-compatible prime-editing system to introduce the Lr67-associated TaSTP13(G144R) resistance allele into the A, B, and D TaSTP13 homoeologs of hexaploid wheat. Edited lines were generated and characterized for editing efficiency, followed by evaluation of le...
Rafael E. Venado, Joshua Waites, Easter D. Syombua et al.· Figshare· 0 citations
Micronutrient deficiencies, particularly of iron (Fe) and zinc (Zn), are major global health concerns for humans, especially in populations that rely heavily on cereal-based diets. Rice grains, one of the world’s most consumed staple crops, have low concentrations of bioavailable Fe and Zn, especially in the endosperm...
P. K. Menguer, Lucas Adamy Lenhardt, Marcos Bönes et al.· Frontiers in Plant Science· 0 citations
Common buckwheat (Fagopyrum esculentum) is a climate-resilient pseudocereal; however, its global adoption is constrained by the heteromorphic self-incompatibility associated with distyly. While the S-locus early flowering 3 (FeS-ELF3) gene has been identified as a key regulator of self-compatibility, a stable genetic t...
Artur Piński, Magdalena Zaranek, Joanna Lusinska et al.· Frontiers in Plant Science· 0 citations
Origanum vulgare is a perennial herb known for its antimicrobial, antioxidant, and anti-inflammatory properties, valued in both traditional medicine and modern phytopharmacology. Despite substantial research on its chemical and pharmacological properties, genomic studies have been limited. In this study, we present the...
Curated dataset and analysis code for a deduplicated census of the mobilized colistin resistance (mcr) gene family in the August 2026 NCBI snapshot (AMRFinderPlus Reference Gene Catalog 2026-08-07.1). Contents. Four archives: (1) core curated datasets (1,298 → 1,106 records, 454 unique proteins, 284-protein QC-triage c...
Shilei Dong· Zenodo (CERN European Organi...· 0 citations
Curated dataset and analysis code for a deduplicated census of the mobilized colistin resistance (mcr) gene family in the August 2026 NCBI snapshot (AMRFinderPlus Reference Gene Catalog 2026-08-07.1). Contents. Four archives: (1) core curated datasets (1,298 → 1,106 records, 454 unique proteins, 284-protein QC-triage c...
Shilei Dong· Zenodo (CERN European Organi...· 0 citations
Exploring how generative AI could make machine vision more accessible to businesses. The post GenEye in a Box: Making Machine Vision Something You Can Just Ask For appeared first on GPT-Lab.
